Conserved Protein Domain Family
PKK
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pfam12474: PKK 
Polo kinase kinase
This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.
Links
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Statistics
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PSSM-Id: 463600
Aligned: 56 rows
Threshold Bit Score: 80.298
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_018667614  959 YQTTKQQIKDQYHLQRHQLVIRHDKEQEQMHRHNKRSREELISHQQQEKVRLPKIQRSEGKARMSMFKRSLRIQSTYegK 1038
XP_015792140 1140 HQLAKRQLEDIIKLQRIQIFTRHEKELEQLKRMSQRQEDQLLKRQAVERRQLPKHIRAEMKARELMFRESLRCSSAN--L 1217
EEZ97987     1050 HQLMKRQIKEIFILQRHQMLTRHEKEKEQIKRRAARKEEELLKKQAAEKRSLPKRIRTEMKARELMFRESMRISISGt-N 1128
XP_002006903 1158 HQLSKRHVKELCFMQRHQMIVRHEKELDQVKRMLQRKEEDLLKKQTLEKRALPKRIRAERKARDLMFRESLRISTN---L 1234
ETN62420     1440 HQLAKRHVKDICFMQRHQMIIRHEKELDQIKRMITRKEEELVKRQTIERRALPKRIRAERKARDMMFRESLRISMT---T 1516
XP_028034415  899 YQLAKRQLKDEFLLRRQQMLVRHDKELEQIKRKNTRKEEELAKCQALEKRSLPKRIRAEQKAREMMFRESLRISTAP--Q 976 
KAE9428136    193 HQLAKRQLKDSFFLQRHQMLIRHDKELEHMKRLNARKVEDLLKRQNIERRAHPKRIKSEMKVREMMFRESLRIRMANn-P 271  Apolygus lucorum
XP_003105520  871 FVLHRKLFKDEYYLLRTQMLARHQREMAQIEKNHQEEEEELIRALTLDRKKLPKMLRAETKTRSVMFKESLRISSTN--M 948 
PDM66189      982 YVLHRRLLKDKFFLLRTQMLARQQKELQQAQKLHAREEEELIRALATDRKRLPKMLRNEAKTRSAMYKESLRISMAD--P 1059
XP_003383893  688 HQLQKQQVREAFHMQRHQMQMRHQKEYDQQLRRDNFRLDELKQTQLFEKKQLPKQLNAEFKVQLNELRKTMGL------R 761 

XP_018667614 1039 AAVNe-rEKIKQFTITETKRMKAEKLKQHLKHEtQLKELDARSEANMRELMQLQNEKRRMVVDHE 1102
XP_015792140 1218 HNVEderERIRKWQESEKLRYKAQQQEQENKHRkQLEDLRAASEAAIRELEHSQNEKRKSLLNYE 1282
EEZ97987     1129 DPEAe-kNKFKEFQEKEKKRYQAEQQRFELKHQrQLEELRAMSDATIKELEQLQNEKRKMLLEHE 1192
XP_002006903 1235 DPEMe-rDRLKKFQEQEKKRYMQEERRFEVKHQkQLEELRATRESAIRELEQLQNEKRKALVEHE 1298
ETN62420     1517 DPELe-rEKLKKFQEQEKKRYNQEQLRFETKHSkQLEELRATSEGSIRELEQLQNEKRKQLLEHE 1580
XP_028034415  977 NHEDd-rDRLKKFQENEKRRYKAEHQRLATKHAkAREELKAQGEAMLRELEQFQNEKRKALMNHE 1040
KAE9428136    272 DPDHe-rNMLKKFQENEKKRYRLEAQRFDQKHQrQQEELRANSEQTIKELEQLQNEKRKMLMEHE 335  Apolygus lucorum
XP_003105520  949 SNSEm-qERIRRFDEQESLRMRAALEDHDMKSQkKLQALKDRHHAAVIELDEMQNEKRKQLLEKE 1012
PDM66189     1060 SGGDi-nDMVRRFDEQEKARVNQALRDHEMKSEkKIQTLKEKNAAEMKELEETQNENRKLLLEKE 1123
XP_003383893  762 RTAEd-kAKLKKLEQRYIIKEESERSLMKEKHTrDLETQKAEMENNIREMVEIQNEKKLTLTQQE 825
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