pfam02761: Cbl_N2 (this model, PSSM-Id:367171 is obsolete and has been replaced by 460681)
CBL proto-oncogene N-terminus, EF hand-like domain
Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.
Jiyao W et al.(2023). "The conserved domain database in 2023.",