6BK5


Conserved Protein Domain Family
Cbl_N2
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pfam02761: Cbl_N2 
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CBL proto-oncogene N-terminus, EF hand-like domain
Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.
Links
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Statistics
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PSSM-Id: 460681
Aligned: 25 rows
Threshold Bit Score: 105.783
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BK5_A       161 FTIVKIDAREFWHRQFGKRLVVPWSELVPIMQAELGLSEKE--GPALQHTMDITENNHVSWFEFDVFTRLFQPWSQLINN 238 Salpingoeca ros...
XP_004364071 198 LKIAKKEAADFWKANFDLRCIVPWHEFLAAFKTVHPISTPQe-ASALRTTMNLTDYNHISWFEFDVFTRLFQPWSHLVNN 276
Q6ABG8       170 FRMTKKEAESFWSHHFTKKNIVPWSTFFTALEKHHGSTIGKmeAAELKATIDLSGDDFISNFEFDVFTRLFYPFKTLIKN 249 Caenorhabditis ...
ESN90703     107 FRVTKNDADEWWKSAFQDKIIIQWKQFRQSFSEVHRIDSAIe-WVALKSTIDLTLNDHISIFEFDVFTRLFQPWRTLLSN 185
XP_009026767  19 YRITKNDASDWWKSVFKKRTLVTWKEFKLAFNQVHKVGTSKe-SDALKTTLDLSCDEHISIFEFDIFTRLFQPWRTLLCN 97 
2_pfamImport   1 FRITKSDAAEFWRNNFGNSTADPIKVCRTEYPQLQKMESIL--RGLIEIFVKIASSGFLKSTAY-TFLLLFQPWTSLLRN 77 
CCD82614     130 FRITKPNAARWWLSNFGDSVVVSWQLFKDSLIQTFRIDSDTq-LLALQTTIDITCNDYVSIFEFDVFTRLFQPWNNILET 208
CDS37021     177 FRITKREAAEWWHENFGESSIVSWEVFRTRLFATFGVLDCNe-TRELQNTIDLTCNNYVSVFEFDVFVRLFQPWTNVLET 255
PDM60022     172 FRLTKREADAFWKTSFKARICVPWAEFIVALAESQRIPENV--KNNLKCTIDLTCNDYVSMFEFDVFTRLFYPWKSLIEN 249
4_pfamImport   1 FRITKKEAESFWSHHFPKKNIVPWPTFLSAIEKYHGMPIEKlqAGDLKATIDLSADDYISSFEFDVFTRLFYPFKNLIKN 80 

6BK5_A       239 WYVLA 243 Salpingoeca rosetta
XP_004364071 277 WNVLA 281
Q6ABG8       250 WQTLT 254 Caenorhabditis elegans
ESN90703     186 WNLLA 190
XP_009026767  98 WNVLA 102
2_pfamImport  78 WQILA 82 
CCD82614     209 WKALA 213
CDS37021     256 WKALT 260
PDM60022     250 WKLLT 254
4_pfamImport  81 WQTLT 85
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