Conserved Protein Domain Family
CEP76-C2
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pfam15627: CEP76-C2 (this model, PSSM-Id:317939 is obsolete and has been replaced by 464781)
CEP76 C2 domain
Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.
Links
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Statistics
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PSSM-Id: 317939
Aligned: 23 rows
Threshold Bit Score: 116.632
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q28DH9       103 VDPTRrYLHLQVLSGKAFLEHlq-----------------eSDplPGQACSTFTLCLHFRNQRFRSKPVPCACEPDFQDG 165 tropical clawed...
Q4D5L5        95 LPGEY-YLHLRLAGGKAFVDNl-------------------DLtpSFAKDYQMYVAVHFGSQRYRSNLEDVSLDPPFRDE 154 Trypanosoma cruzi
Q384E2        95 LPGEY-YLHVRLAGGKAFVDNl-------------------DIapSVAQDYHMYVALQFGPHRYRSVSQDVSVDPPFRDE 154 Trypanosoma brucei
A0BKF5        87 INYRS--VSLRIYKGRAFLDFi------------------------EPQNQKLQLYLSFCGQRFASATVDATVEPEFNEL 140 Paramecium tetr...
XP_002680837  94 dlKKNkILHMRLLGGNAFMEYd----------------------dNVKTDEKMICFLNYKDQRFVSQPVSCCCNPIFEED 151 Naegleria grube...
GAA48487      98 KPPFTvGLVVEIFRGTAFIEHigsy-------------rdyILeeKGQVKSAVIIYLACGRYRACSKLVPFTSEVNFGEE 164 Clonorchis sine...
XP_002948818  70 LPAGKaFLHVKLLGGRAFTDYtl-----------------rI----PGPEERLQLSLELFGQRFTTHEVPATAEPAFAGE 128 Volvox carteri ...
XP_002997419  91 ENDRDvFLYLRLSTGKAFVDQlveleqdtknadqddvgldeKRcpVGSVVTFFRVNVTFQTQRQTSRDIRCCVDPPFDEH 170 Phytophthora in...
XP_001470249  92 sDGRH-YLLVRVNGGRAFVDNl-------------------DLapSTVSKRSVVFAAHFGNQRFRSAVKPCSAEPKFDEE 151 Leishmania infa...
EPR62238     141 NDPp--YLLCRFSDGHDFSEY---------------------EdeSRHSGSYFVIHMSFGSQRFRSRPVEACCEPQFLET 197 Toxoplasma gond...

Q28DH9       166 FLLEV--HKDslg----------dgSRMADATTMLSICDPVQ----LVLLKT---------DTSGETS------------ 208 tropical clawed...
Q4D5L5       155 FLIDL--DYK---------------SFGSCAADLIEVSTPLH----IAVFRE---------ERLLTFSk----------- 193 Trypanosoma cruzi
Q384E2       155 FLIHL--DYK---------------AFGTSALDLIEISTPFN----LAVIRE---------DRFLSTAt----------- 193 Trypanosoma brucei
A0BKF5       141 FLFDL--RTEa-------------qKANVDLLTLSKLDHPIE----LCVIQI---------QNGQRK------------- 179 Paramecium tetr...
XP_002680837 152 FIIDL--EIEnirnvf----tdqqeDADDGVGALLQISTPID----IIILSV---------DSEGRTK------------ 200 Naegleria grube...
GAA48487     165 FCFPLmtDTEd-------------nRSTGPQQILLANSTPAHhlhiVVVSRE---------YDTGRTN------------ 210 Clonorchis sine...
XP_002948818 129 AFFQL--PTg---------------PGSVDPLQLLALRQGLH----AVVMQLnplapwgsdDQAGQRDr----------- 176 Volvox carteri ...
XP_002997419 171 FRFRV--EKKrtrtartrggasyavDVMAPWEALCLVEEPVQ----LNLVKV---------TKKLQSRnsngtaq----- 230 Phytophthora in...
XP_001470249 152 FLFEV--DAT---------------GFGFGEADLIEVSTPFH----IAVLRE---------DSQLNVAe----------- 190 Leishmania infa...
EPR62238     198 FAARL--PTE----------------EGASYRDLLKRQLPLH----LVVTKE---------DVISHSSwtkggiasnrat 246 Toxoplasma gond...

Q28DH9       209 ---------------LVSSHFLEWRSVLGTekGATS----------LVVELl-----gVgaeCKVSVGIL---------N 249 tropical clawed...
Q4D5L5       194 ---------------MVGENIVDWRKVLRT--GYLG----------LTVEL-------CgdnPGIPAGIL---------E 230 Trypanosoma cruzi
Q384E2       194 ---------------MVGENVVDWRKVLRT--GYLG----------LTVEL-------CgenPGIPAGII---------E 230 Trypanosoma brucei
A0BKF5       180 ---------------LFSQKLIEWRFLLCY-----Gni-------sLNIELpttyntkMqneRKNHVGIL---------Q 223 Paramecium tetr...
XP_002680837 201 ---------------YIGGHRLEWRRVLKK--GVIL----------MTIELgg----gSgieSKVSKGIL---------E 240 Naegleria grube...
GAA48487     211 ---------------LVASTVLDWRRHLFHntNSTQtaaqqpwtasFPLELk-----sVdpdSKMTAGIL---------D 261 Clonorchis sine...
XP_002948818 177 ---------------------------------------------------------gAgpgKAPTAAAVantpeqvarQ 199 Volvox carteri ...
XP_002997419 231 --------wrelsseLLAVYRMDWRRVLCStlQLVH----------FPIQLt-----gI---MKEPVGSL---------D 275 Phytophthora in...
XP_001470249 191 ---------------LLGENIIEWRKVLKS--GYLG----------LTVEL-------CgrnAGVPAGIV---------D 227 Leishmania infa...
EPR62238     247 tpresfsgntmykskILSSQKVEWQRVLHC--GKIH----------TSVKLr-----gVgtrEALSVGKL---------D 300 Toxoplasma gond...

Q28DH9       250 VKLELYPLLN 259 tropical clawed frog
Q4D5L5       231 LQLELLPNKA 240 Trypanosoma cruzi
Q384E2       231 LQIEILPNKA 240 Trypanosoma brucei
A0BKF5       224 IHLELLPKTg 233 Paramecium tetraurelia
XP_002680837 241 IRLELLPRPN 250 Naegleria gruberi strain NEG-M
GAA48487     262 LRLSMVWNLP 271 Clonorchis sinensis
XP_002948818 200 LSLELRPAFS 209 Volvox carteri f. nagariensis
XP_002997419 276 IRADLLNCKR 285 Phytophthora infestans T30-4
XP_001470249 228 LQLELVSKKR 237 Leishmania infantum JPCM5
EPR62238     301 MEIQLLPRDE 310 Toxoplasma gondii GT1
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