Conserved Protein Domain Family
CEP76-C2

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pfam15627: CEP76-C2 
CEP76 C2 domain
Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.
Statistics
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PSSM-Id: 464781
Aligned: 21 rows
Threshold Bit Score: 117.055
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEY68727      89 ALENDRD-VFLYLRLSTGKAFVDQLveleqdtknadqddvglDEKRCPVGSVVTFFRVNVTFQTQRQTSRDIRCCVDPPF 167
EDV29045      70 MKIDPSK-RYLYVQMLGGRAFLEHIl----------------DEDRSTEKNYNGTLSIHIHFRQQRFQSRPILCACEPDL 132
XP_019849903 103 EAKSSKHvQCIYFQVLQGRAFVDHL-----------------TSVTELLSQDTSTFTLHVYFRHQRFQSSAVPCSCEPEF 165
A0BKF5        85 DRINYRS---VSLRIYKGRAFLDF-------------------I-----EPQNQKLQLYLSFCGQRFASATVDATVEPEF 137 Paramecium tetr...
XP_002948818  68 AELPAGK-AFLHVKLLGGRAFTDYTlr-------------ipGP--------EERLQLSLELFGQRFTTHEVPATAEPAF 125
EFC48093      92 KKDLKKN-KILHMRLLGGNAFMEY----------------------DDNVKTDEKMICFLNYKDQRFVSQPVSCCCNPIF 148
CAM69444      92 S--DGRH--YLLVRVNGGRAFVDN-------------------LDLAPSTVSKRSVVFAAHFGNQRFRSAVKPCSAEPKF 148
Q4D5L5        93 KLLPGEY--YLHLRLAGGKAFVDN-------------------LDLTPSFAKDYQMYVAVHFGSQRYRSNLEDVSLDPPF 151 Trypanosoma cruzi
Q384E2        93 KLLPGEY--YLHVRLAGGKAFVDN-------------------LDIAPSVAQDYHMYVALQFGPHRYRSVSQDVSVDPPF 151 Trypanosoma brucei
ESS32622     139 DPNDP---PYLLCRFSDGHDFSEY---------------------EDESRHSGSYFVIHMSFGSQRFRSRPVEACCEPQF 194
EEY68727     168 DEHFRFRVEKKrtrtartrggasyAVDVMAPWEALCLVEEPVQLNLVKV---------TKKLQSRnsngtaq-------- 230
EDV29045     133 RDGFLLQLPQH-------------KVSARSDPTSLLSIAEPIHLLLIRN---------EPNGDKT--------------- 175
XP_019849903 166 KEGFLLELPKE-------------------GKDDWITSPELIHIILTRT---------HPNREGTtr------------- 204
A0BKF5       138 NELFLFDLRTE-------------AQKANVDLLTLSKLDHPIELCVIQI---------QNGQRK---------------- 179 Paramecium tetr...
XP_002948818 126 AGEAFFQLPTG---------------PGSVDPLQLLALRQGLHAVVMQLnplapwgsdDQAGQRD--------------- 175
EFC48093     149 EEDFIIDLEIEnirnv----ftdqQEDADDGVGALLQISTPIDIIILSV---------DSEGRTK--------------- 200
CAM69444     149 DEEFLFEVDAT---------------GFGFGEADLIEVSTPFHIAVLRE---------DSQLNVAe-------------- 190
Q4D5L5       152 RDEFLIDLDYK---------------SFGSCAADLIEVSTPLHIAVFRE---------ERLLTFSk-------------- 193 Trypanosoma cruzi
Q384E2       152 RDEFLIHLDYK---------------AFGTSALDLIEISTPFNLAVIRE---------DRFLSTAt-------------- 193 Trypanosoma brucei
ESS32622     195 LETFAARLPTE----------------EGASYRDLLKRQLPLHLVVTKE---------DVISHSSwtkggiasnrattpr 249
EEY68727     231 -----wrelsseLLAVYRMDWRRVLCSTLQLVH---FPIQL-----TGI---MKEPVGSL---------DIRADLLNCKR 285
EDV29045     176 ------------LLSSTYLEWRKVLSSSHNRWT---TAVEL-----NGIgpeAKLSVGLL---------DLKIELIPRSl 226
XP_019849903 205 -----------eLVGSYLLDWRSVLASPNNKIN---KSFEL-----IGPradGRVSPGVL---------TLQWELFPHER 256
A0BKF5       180 ------------LFSQKLIEWRFLLCY-----GnisLNIELpttynTKMqneRKNHVGIL---------QIHLELLPKTg 233 Paramecium tetr...
XP_002948818 176 ----------------------------------------------RGAgpgKAPTAAAVantpeqvarQLSLELRPAFS 209
EFC48093     201 ------------YIGGHRLEWRRVLKK--GVIL---MTIELg----GGSgieSKVSKGIL---------EIRLELLPRPN 250
CAM69444     191 ------------LLGENIIEWRKVLKS--GYLG---LTVEL-------CgrnAGVPAGIV---------DLQLELVSKKR 237
Q4D5L5       194 ------------MVGENIVDWRKVLRT--GYLG---LTVEL-------CgdnPGIPAGIL---------ELQLELLPNKA 240 Trypanosoma cruzi
Q384E2       194 ------------MVGENVVDWRKVLRT--GYLG---LTVEL-------CgenPGIPAGII---------ELQIEILPNKA 240 Trypanosoma brucei
ESS32622     250 esfsgntmykskILSSQKVEWQRVLHC--GKIH---TSVKL-----RGVgtrEALSVGKL---------DMEIQLLPRDE 310
EEY68727     286 T 286
EDV29045     227 e 227
XP_019849903 257 S 257
A0BKF5       234 l 234 Paramecium tetraurelia
XP_002948818 210 A 210
EFC48093     251 S 251
CAM69444     238 i 238
Q4D5L5       241 p 241 Trypanosoma cruzi
Q384E2       241 p 241 Trypanosoma brucei
ESS32622     311 T 311
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