Conserved Protein Domain Family
artemis-SNM1C-like_MBL-fold
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cd16297: artemis-SNM1C-like_MBL-fold 
artemis-SNM1C and related proteins; MBL-fold metallo-hydrolase domain
Includes the nuclease artemis (also known as SNM1C, SNM1 homolog C, SNM1-like protein and DNA cross-link repair 1C protein) which plays a role in V(D)J recombination/DNA repair. Purified artemis protein possesses single-strand-specific 5' to 3' exonuclease activity. Upon complex formation with, and phosphorylation by, DNA-dependent protein kinase, artemis gains endonucleolytic activity on hairpins and 5' and 3' overhangs. Inactivation of Artemis causes severe combined immunodeficiency (SCID). Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293855
Aligned: 5 rows
Threshold Bit Score: 332.164
Created: 11-Sep-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        # # ##                                          
XP_002935298   1 MSSFmGRMKEYPAISIDRFDRENLSARAYFLSHCHKDHMKGLRAPFlkrrlqnslkVHLYCSPVTKELLLTNpkyafWEN 80  western clawed ...
Q5QJC2         1 MSRFgGRLREYPQLSIDRFDYDNLRARAYFLSHCHKDHMKGLRAPAlrrrlqsslkVKLYCSPVTKELLLTNskyafWEN 80  chicken
CAC37570       1 MSSFeGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTlkrrlecslkVYLYCSPVTKELLLTSpkyrfWKK 80  human
Q5RGE5         1 MSSFaGRMKEYPSISLDRFDRENLHARAYFLSHCHKDHMKGLKGPLlkrklkfsltVKLYCSYVTKELLLSNpryafWED 80  zebrafish
EEN57777       1 MSCFgGRMSEYRYLSIDRFDGENLESWAFFLSHAHRDHMVGLDNPGflsrlkaslkTRLYCSDITKALLLTEkqfkpLEP 80  Florida lancelet

Feature 1                                          ##                   #                        
XP_002935298  81 RMISIEIDTPTQIslvdeatgykedvVVTLLPAGHCPGSVMFLFQgnsgTVLYTGDFRLAKGEVARMELLhsgnrvkdIE 160 western clawed ...
Q5QJC2        81 HIVALEVETPTQIslvdettgekediEVTLLPAGHCPGSVMFLFQgengTVLYTGDFRLAKGEAARMELLhsgtsvkdIQ 160 chicken
CAC37570      81 RIISIEIETPTQIslvdeasgekeeiVVTLLPAGHCPGSVMFLFQgnngTVLYTGDFRLAQGEAARMELLhsggrvkdIQ 160 human
Q5RGE5        81 HIVPLELDSPTSIslidestgetedvVVTLLSAGHCPGSVMFLFEgakgTVLYTGDFRLAVGDAARMEYLhsgdrvkdIQ 160 zebrafish
EEN57777      81 YIVSVQIDTPTSLtvtdevtgkehslLVTLLQAGHCPGSVMFLFEglegTVLYTGDFRLPVGGAAQFQHLhqgdrlkdIQ 160 Florida lancelet

Feature 1             #     
XP_002935298 161 SVYLDTTFCDP 171 western clawed frog
Q5QJC2       161 SVYLDTTFCDP 171 chicken
CAC37570     161 SVYLDTTFCDP 171 human
Q5RGE5       161 SVYIDTTFFDP 171 zebrafish
EEN57777     161 SLYVDTTFLVP 171 Florida lancelet

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