pfam16489: GAIN (this model, PSSM-Id:293098 is obsolete and has been replaced by 465137)
GPCR-Autoproteolysis INducing (GAIN) domain
The GAIN a domain of alpha-helices and beta-strands that is found in cell-adhesion GPCRs and precedes the GPS motif where the autoproteolysis occurs, family, pfam01825. The full GAIN domain, comprises the GPS and the GAIN, in cell-adhesion GPCRs, and is the functional unit for autoproteolysis. The GPS motif at the end of the GAIN domain is an ancient domain that exists in primitive ancestor organizms, and the full GAIN + GPS is conserved in all cell-adhesion GPCRs and all PKD1-related proteins.
Jiyao W et al.(2023). "The conserved domain database in 2023.",