Conserved Protein Domain Family
EZH2_WD-Binding
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pfam11616: EZH2_WD-Binding (this model, PSSM-Id:288468 is obsolete and has been replaced by 463308)
WD repeat binding protein EZH2
This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.
Links
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Statistics
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PSSM-Id: 288468
Aligned: 12 rows
Threshold Bit Score: 53.2282
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q29RB7        45 KALFQSNRRKIEVGTELLNEEWSKLRIQS 73  zebrafish
EPY88163      49 KALYVANFAKVQEKTQILNEEWKKLRVQP 77  Wild Bactrian camel
ETE65535      61 KNLFVSNFTKIQEKINILNDDWKKLRVQP 89  king cobra
XP_005994088  54 KSLFTANRNKVKERTEVLNEDWKKLRVQP 82  coelacanth
XP_003222404  44 KALFASNYAKVQEKLDILNDDWKNLRVQP 72  green anole
XP_002932548  55 rmfYVENLTKAQERAHLLNEDWKKLRVQP 83  western clawed frog
XP_008414068  61 KSLFMSNRQKIELQTNLLNTEWSKLRIQA 89  guppy
XP_003964923  57 KALFMSNRRKIEQQTNVLNAEWSALRIQS 85  torafugu
NP_001265765  58 KTLFSSNREKIEQQTTVLNSEWSTLKIQS 86  Japanese medaka
XP_006638261 100 qsqFMANRSKIKEKTELLNDEWSNLRIQP 128 spotted gar
XP_006004388  39 KSMFNSNRQKIQEKTEILNQEWKQRRIQP 67  coelacanth
CAF90425      36 KSMFSTNRQKIMERTDILNQEWKTRRIQP 64  spotted green pufferfish
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