Conserved Protein Domain Family
LNS2
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pfam08235: LNS2 (this model, PSSM-Id:285447 is obsolete and has been replaced by 462403)
LNS2 (Lipin/Ned1/Smp2)
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins. SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.
Links
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Statistics
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PSSM-Id: 285447
Aligned: 92 rows
Threshold Bit Score: 273.573
Created: 20-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8SWG3        346 KLNSE--ELRMLNLKEGKNQVVFKISG---LN-KQ-LEGSIYLWRSNAKIIVSDIDGTITK-----------SDVWGHLY 407  Encephalitozo...
A0D325        146 VPTSK--TIQSLKLKHGLNTITYEVECkrlGL-QH-IECQLFMIKQNQKIFISDIDGTITK-----------SPTKGMIL 210  Paramecium te...
Q582G0        396 VPMEA--DLLKLNLVPGHNRIRYITHSslrGE-VA-VEANVYLWDSTDRLVISDVDGTITK-----------SDVLGHIM 460  Trypanosoma b...
Q4DCR5        409 IPTEA--DLRKLNLVEGHNQVRYITHSslrGE-VA-VDANVYLWDSTDRLVVSDVDGTITK-----------SDLWGHLM 473  Trypanosoma c...
XP_004037123   98 RPSNS--LLNLFNLRKGYNKIEFIINTelqGE-HV-IEGKIYLFNYEAKLVISDVDGTITK-----------SDIKGHIN 162  Ichthyophthir...
XP_002677637  290 RPSKEylELIHSHMTDGRSSISFIdp---nGG-LEpVKAYIFEFSPQDKIIISDIDGTITK-----------SDIMGQVY 354  Naegleria gru...
XP_009524978  350 KPSQE--ELLSMGLRVGTNDISFVLRShgaGEvAR-VSANLYLWPVTAKVVIAQIDGAISS-----------SAATGSMF 415  Phytophthora ...
CBJ48752     1118 RPTSE--QLAALRLRPGCNTIEFVVNVagqAE-RV-VSARAFLWGSGARVVVSDIENTIARsggggsgrgsfSQVIG--- 1190 Ectocarpus si...
XP_001463166  615 IPVEA--DLWKLHLKEGCNTVRYLARKdkgDI-VS-ISCNIFLWNWTDRLVVSDVDGTITK-----------SDLLGHFY 679  Leishmania in...
EIJ88311      244 YLPDT--YIEKMHLVPGPNKTVYRLS----GT-PIfLTCNIYLWNETDKIIISDIDGTVTK-----------SDIVGYIY 305  Nematocida pa...

Q8SWG3        408 GMMGK--DWTHHGVASLYTKIVRNGYKIVYLTARPLGQSFSTKSYLKNV--CQDGYKLPDGPVILSPDGVFAALYRELII 483  Encephalitozo...
A0D325        211 STFGR--DYTQDHICEFYNRLTQRNYLILYMSARSMVQYESTKEYLLRQ--QQQGIQLPPGPLFLSPQELLEAFTIEVIK 286  Paramecium te...
Q582G0        461 PLIGR--DWTHPGICSLYSQIQKNGYRLVYLTARSVSQISMTRKFLWNI--QQNGVSLPKGPVLTAPKRLFSALAQEV-A 535  Trypanosoma b...
Q4DCR5        474 PLIGR--DWTHPGICSLYSKIDRNGYKFVYLTARSVSQVSMTRNFLWNI--EQDGFRLPKGPVLTAPQRFFTALTQEV-S 548  Trypanosoma c...
XP_004037123  163 YMLGK--QWTHDDIAQLYTQIQKNGYKIVYLSSRPITLYNYTQKYLKNI--QQNGYKMPDGPTLLSPDLLLNSVNREVIL 238  Ichthyophthir...
XP_002677637  355 SRMGK--DYTHPGIAKLFQSIAENNYKFIYLSARPITMSQLTREYINSV--YQDGYKMPPGPIITSPNKAFSALAREVVI 430  Naegleria gru...
XP_009524978  416 KRRDP--AAMHPGAVEFYSQLARNGYRVVYVTCHGLSQANMLHTLLHNSsaEDGEIALPMGPVLLSPDRLLATYSNEMI- 492  Phytophthora ...
CBJ48752     1191 -------PGVHKDVSTLFSKISGNGYKILYLTNRPLPDWHAKRG-AAAA--AEGGVALPRGPVLCPPEVLFRGTSSKDRR 1260 Ectocarpus si...
XP_001463166  680 AMLGKgaDWTHPGICNLYSKIERNGYRMVYLTARSVSQINQTKSYLFTL--QQDGVRLPMGPVLTAPQRFFTALTQEV-S 756  Leishmania in...
EIJ88311      306 GAMGK--DWTHLGIAALYNKIVENGYKIVYLSSRPIGHIGFTKAYLERV--EQEEQNLPAGPVILFPGRLLSAIYREMV- 380  Nematocida pa...

Q8SWG3        484 RRPEDFKIAYLKTIqeLFGdt--nPFVAGFGNKITDVITYKALEVPLSRIFTINH-KGELyvelVKTLSGT-YR--TMND 557  Encephalitozo...
A0D325        287 KQTDILKSQMLNDL--VFTigvtgTIQGGMGDRLNDIQAYKMANIEYERILLINK-KGEIvr-vNNEMKEEkFTikEIIQ 362  Paramecium te...
Q582G0        536 MKSHFFKIACLQKVvnAFPqk-tkPFYAGFGNRLSDMLSYLAVMVPEHKIYVVDS-KSLVrv---aNVTST-YQ--RLAD 607  Trypanosoma b...
Q4DCR5        549 KKSHVFKIACLKSVldTFPaq-skPFYAGFGNRFNDVVSYTATQIPQHKIFIIDP-NSVLhv---yNVRQT-YK--NLAH 620  Trypanosoma c...
XP_004037123  239 KKADEFKGALLKDIqgLFPig-tnPIFAGFGNRDTDAIACLYAGIQVENIYIINE-KGEIen-iGKRQIFS-YK--KIYL 312  Ichthyophthir...
XP_002677637  431 RRPETFKINCLGSIasLFPtd--fPFYSGFGNRPTDCISYVSVNIDPTRCYRINK-QGKLlvqaTKVTYNS-YA--EIES 504  Naegleria gru...
XP_009524978  493 -DAQDFKVAALGALrsLFPrd-vnPFYAAFGTTQTDSIVFTQVGVFSGKVFVVDPaDGTLrhrsLLGFRES-YS--SLMD 567  Phytophthora ...
CBJ48752     1261 SHHEVFKMTALRGLklIFPad-vnPLYGGFGNSVSDMVAYKKMAVPEGRIFLINS-MGELhn-iNHTYRQT-YL--SLSR 1334 Ectocarpus si...
XP_001463166  757 KQSHVFKIACLTSVraAFPps-tkPFFAGFGNRYNDVISYDAAGIPTHKIFIIDP-SSVLhv---cLVRQT-YR--DLGH 828  Leishmania in...
EIJ88311      381 QGPEEFKISVISEIkgLMSq---gRIYAGFGNKESDRIAYEVCEIDPGRIFIVNT-MSEIstgrKGIVKLT-HC--SLYD 453  Nematocida pa...

Q8SWG3        558 FVDSMF 563  Encephalitozoon cuniculi
A0D325        363 KMDQIF 368  Paramecium tetraurelia
Q582G0        608 DVDSSF 613  Trypanosoma brucei
Q4DCR5        621 LVDVTF 626  Trypanosoma cruzi
XP_004037123  313 NQQELF 318  Ichthyophthirius multifiliis
XP_002677637  505 QLLKHF 510  Naegleria gruberi strain NEG-M
XP_009524978  568 RMDGMF 573  Phytophthora sojae
CBJ48752     1335 HVDLTF 1340 Ectocarpus siliculosus
XP_001463166  829 LVDVTF 834  Leishmania infantum JPCM5
EIJ88311      454 IVDGVF 459  Nematocida parisii ERTm3
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