Conserved Protein Domain Family
LNS2

?
pfam08235: LNS2 
LNS2 (Lipin/Ned1/Smp2)
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571). SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.
Statistics
?
PSSM-Id: 462403
Aligned: 74 rows
Threshold Bit Score: 272.073
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_001730129  603 KTLRLSSDQL--KQLGLRKGTNTITFSVTSSYSGVAT-CRARIFLWDCDQPVVVSDIDGTITKS----DALGHVFTLMGR 675 
EJW03258      403 LTLKLSSKQL--ERMELKPGKNELQFKIDG---TNQC-ISTNCYFWENDVKIIISDIDGTITKS----DKLGHVYTMIGK 472 
EIJ88311      241 REVYLPDTYI--EKMHLVPGPNKTVYRLS----GTPIfLTCNIYLWNETDKIIISDIDGTVTKS----DIVGYIYGAMGK 310 
EFC44893      287 HRLRPSKEYLelIHSHMTDGRSSISF---IDPNGGLEpVKAYIFEFSPQDKIIISDIDGTITKS----DIMGQVYSRMGK 359 
XP_001463166  612 RTIIPVEADL--WKLHLKEGCNTVRYLARKDKGDIVS-ISCNIFLWNWTDRLVVSDVDGTITKS----DLLGHFYAMLGK 684 
Q4DCR5        406 RTLIPTEADL--RKLNLVEGHNQVRYITHSSLRGEVA-VDANVYLWDSTDRLVVSDVDGTITKS----DLWGHLMPLIGR 478  Trypanosoma c...
Q582G0        393 RSLVPMEADL--LKLNLVPGHNRIRYITHSSLRGEVA-VEANVYLWDSTDRLVISDVDGTITKS----DVLGHIMPLIGR 465  Trypanosoma b...
A0D325        143 LSRVPTSKTI--QSLKLKHGLNTITYEVECKRLGLQH-IECQLFMIKQNQKIFISDIDGTITKS----PTKGMILSTFGR 215  Paramecium te...
CBJ48752     1115 KTLRPTSEQL--AALRLRPGCNTIEFVVNVAGQAERV-VSARAFLWGSGARVVVSDIENTIARSggggSGRGSFSQVIG- 1190
5_pfamImport    1 KSLRPSQEEL--LAMGLRVGTNDIAFVLTSQGANEVArVTANLYLWPVTTKVVIAQIDGAISSR----AATGSM----FK 70  
XP_001730129  676 ----DWTHLGVAKLYHDIAKNGYRLMYLTSRAIGQADITRDYLRNINQ-NN-YQLPDGPVIMSPDRLIASLHREVILRKP 749 
EJW03258      473 ----DWTHAGVAGLFTKIVKNDYKIVYLSSRPIGQMEYTKKYLSGIKQ-NG-CELPDGPVLLSPDGLFGAIYREMILKRP 546 
EIJ88311      311 ----DWTHLGIAALYNKIVENGYKIVYLSSRPIGHIGFTKAYLERVEQ-EE-QNLPAGPVILFPGRLLSAIYREMV-QGP 383 
EFC44893      360 ----DYTHPGIAKLFQSIAENNYKFIYLSARPITMSQLTREYINSVYQ-DG-YKMPPGPIITSPNKAFSALAREVVIRRP 433 
XP_001463166  685 g--aDWTHPGICNLYSKIERNGYRMVYLTARSVSQINQTKSYLFTLQQ-DG-VRLPMGPVLTAPQRFFTALTQEV-SKQS 759 
Q4DCR5        479 ----DWTHPGICSLYSKIDRNGYKFVYLTARSVSQVSMTRNFLWNIEQ-DG-FRLPKGPVLTAPQRFFTALTQEV-SKKS 551  Trypanosoma c...
Q582G0        466 ----DWTHPGICSLYSQIQKNGYRLVYLTARSVSQISMTRKFLWNIQQ-NG-VSLPKGPVLTAPKRLFSALAQEV-AMKS 538  Trypanosoma b...
A0D325        216 ----DYTQDHICEFYNRLTQRNYLILYMSARSMVQYESTKEYLLRQQQ-QG-IQLPPGPLFLSPQELLEAFTIEVIKKQT 289  Paramecium te...
CBJ48752     1191 ----PGVHKDVSTLFSKISGNGYKILYLTNRPLPDWHAKRGAAAAA---EGgVALPRGPVLCPPEVLFRGTSSKDRRSHH 1263
5_pfamImport   71 rrdpAAMHSGAVEFYTKLVQNGYQVVYVTCRGLSQVNLLHTLLSKTTGyDGdMTLPTGPVLFSPDRLLPTSSLRLI--DV 148 
XP_001730129  750 EVFKMACLRDIARLFGidpsqpdsehRT--PFYAGFGNRITDALSYRSVNIPSSRIFTIDS-NGEVKMEllELAGYHTS- 825 
EJW03258      547 EEFKIACLKTLQSLFSt------------nPLFGGFGNRQTDVITYRTVGIDISRIFTIDS-YGVIIPE--CSTTISGS- 610 
EIJ88311      384 EEFKISVISEIKGLMSq------------gRIYAGFGNKESDRIAYEVCEIDPGRIFIVNT-MSEISTG--RKGIVKLT- 447 
EFC44893      434 ETFKINCLGSIASLFP-----------TdfPFYSGFGNRPTDCISYVSVNIDPTRCYRINK-QGKLLVQ--ATKVTYNS- 498 
XP_001463166  760 HVFKIACLTSVRAAFPp--------sTK--PFFAGFGNRYNDVISYDAAGIPTHKIFIIDP-SSVLHVC-----LVRQT- 822 
Q4DCR5        552 HVFKIACLKSVLDTFPa--------qSK--PFYAGFGNRFNDVVSYTATQIPQHKIFIIDP-NSVLHVY-----NVRQT- 614  Trypanosoma c...
Q582G0        539 HFFKIACLQKVVNAFPq--------kTK--PFYAGFGNRLSDMLSYLAVMVPEHKIYVVDS-KSLVRVA-----NVTST- 601  Trypanosoma b...
A0D325        290 DILKSQMLNDL--VFTigv---------tgTIQGGMGDRLNDIQAYKMANIEYERILLINK-KGEIv---rVNNEMKEEk 354  Paramecium te...
CBJ48752     1264 EVFKMTALRGLKLIFPa--------dVN--PLYGGFGNSVSDMVAYKKMAVPEGRIFLINS-MGEL-HN--INHTYRQT- 1328
5_pfamImport  149 QDFKVAALDALRSLFPc--------cVN--PFYAAFGTTQTDSIVLTQAGVFPGKVFIVNPaSGSLRHH--SLTRFQES- 215 
XP_001730129  826 YP--NMTDLVDQMFP 838 
EJW03258      611 YL--TLNSIVDNIFP 623 
EIJ88311      448 HC--SLYDIVDGVFP 460 
EFC44893      499 YA--EIESQLLKHFP 511 
XP_001463166  823 YR--DLGHLVDVTFP 835 
Q4DCR5        615 YK--NLAHLVDVTFP 627  Trypanosoma cruzi
Q582G0        602 YQ--RLADDVDSSFP 614  Trypanosoma brucei
A0D325        355 FTikEIIQKMDQIF- 368  Paramecium tetraurelia
CBJ48752     1329 YL--SLSRHVDLTFP 1341
5_pfamImport  216 YE--SLVNRMDTMFP 228 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap