3ZMI,2NR9


Conserved Protein Domain Family
Rhomboid

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pfam01694: Rhomboid (this model, PSSM-Id:279958 is obsolete and has been replaced by 426384)
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Rhomboid family
This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
Statistics
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PSSM-Id: 279958
Aligned: 62 rows
Threshold Bit Score: 76.1171
Created: 20-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZMI_A  38 PTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRL---GSGKLIVITLISALLS---GYVQQKFSGPW------ 105 Escherichia coli
Q9AQU7  85 IIHYCDLTRFFLSAFYHLSETHFFFNMSSLLWKGIQLETSM---GSVEFASMVAALLGMS---QGITLLLSKGLl----- 153 Japanese rice
Q19821 160 PKLRGEAWRFTSYMFLHAgLNHLLGNVIIQLLVGIPLEVAH---KIWRIGPIYLLAVTSG---SLLQYAIDPNSl----- 228 Caenorhabditis elegans
O75783 239 PGHRARAWRFLTYMFMHVgLEQLGFNALLQLMIGVPLEMVH---GLLRISLLYLAGVLAG---SLTVSITDMRAp----- 307 human
Q9W0F1 107 pDKRHEIWRFLFYMVLHAgWLHLGFNVAVQLVFGLPLEMVH---GSTRIACIYFSGVLAG---SLGTSIFDPDVf----- 175 fruit fly
Q9W0F8 129 PDQRLQLWRFLSYALLHAsWLHLGYNVLTQLLFGVPLELVH---GSLRTGVIYMAGVLAG---SLGTSVVDSEVf----- 197 fruit fly
P20350 144 PDRRLQVWRFFSYMFLHAnWFHLGFNIVIQLFFGIPLEVMH---GTARIGVIYMAGVFAG---SLGTSVVDSEVf----- 212 fruit fly
O74926  50 LLQKRQLYEIITYVTLHLsMLHIVFNFVSLLPAMSQFEKKQ---GTLACILVTVIPYTLFp--GIMHLIVYHFFlrkd-- 122 Schizosaccharomyces p...
Q9M1B5  45 TAIEGHYWRMITSALSHISVLHLVFNMSALWSLGVVEQLGHvglGTAYYLHYTLVLVVFSgvlVIGIYHLLIARfkidy- 123 thale cress
Q8LB17  58 IISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIM---GSVRLLYLTVLLATTNavlHLLIASLAGYNpfyqyd 134 thale cress
3ZMI_A 106 ------FGGLSGVVYALMGYVWLRGERDPQS------GIYLQRGLiIFALIWIV----AGWFDLFGmsma---------- 159 Escherichia coli
Q9AQU7 154 ------LFGNDEAYYDQYAVGFSGVLFGMKVvlnawsDDYVFLHGvVIPAKYAAwa-eLLLIQAFIpgts---------- 216 Japanese rice
Q19821 229 ------LVGASAGVYALIFAHVANVILNWHEmp---lRWIRVLVLfVFIFLDFGg---AIHRRFYTndcds--------- 287 Caenorhabditis elegans
O75783 308 ------VVGGSGGVYALCSAHLANVVMNWAGmrc-pyKLLRMVLAlVCMSSEVGr---AVWLRFSPplpasgp------- 370 human
Q9W0F1 176 ------LVGASGGVYALLAAHLANVLLNYHQmr---yGVIKLLHIlVFVSFDFGf---AIYARYAGdelqlgssseflai 243 fruit fly
Q9W0F8 198 ------LVGASGGVYALLAAQLASLLLNFGQmr---hGVIQLMAViLFVFCDLGy---ALYSRELamhqlqtr------- 258 fruit fly
P20350 213 ------LVGASGGVYALLAAHLANITLNYAHmk---sASTQLGSVvIFVSCDLGy---ALYTQYFdgsafakg------- 273 fruit fly
O74926 123 ---yvsIAGLSGWAFAFISASCVHSPQRLISf----fNLFSIPAYcFPIIYLIMttilVPKASFIG-------------- 181 Schizosaccharomyces p...
Q9M1B5 124 -frrvtAVGYSCVVFGWMTILSVKQPSSKLNl----fGLLSLPISfAPFESLIFtsiiVPQASFLG-------------- 184 thale cress
Q8LB17 135 hlmnecAIGFSGILFSMIVIETSLSGVTSRSv----fGLFNVPAKlYPWILLIVfqllMTNVSLLG-------------- 196 thale cress
3ZMI_A 160 ----------ngaHIAGLAVGLAMAFVDSL 179 Escherichia coli
Q9AQU7 217 ----------ligHLGGILAGLAYLWLKRS 236 Japanese rice
Q19821 288 --------vshlaHIAGAVTGLFFGYVVLY 309 Caenorhabditis elegans
O75783 371 -------qpsfmaHLAGAVVGVSMGLTILR 393 human
Q9W0F1 244 dqaetagavsyvaHLAGAIAGLTIGLLVLK 273 fruit fly
Q9W0F8 259 ------psvsyiaHMTGALAGISVGLLLLR 282 fruit fly
P20350 274 ------pqvsyiaHLTGALAGLTIGFLVLK 297 fruit fly
O74926 182 -------------HASGAVMGYCTPFMLGS 198 Schizosaccharomyces pombe 972h-
Q9M1B5 185 -------------HLSGILVGYAISWGLIG 201 thale cress
Q8LB17 197 -------------HLCGILSGFSYSYGLFN 213 thale cress
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