1GUX,1TFB,1C9B,1AIS,1D3U,1JKW,1BU2,1F5Q,1VIN,1G3N,1QMZ


Conserved Protein Domain Family
CYCLIN
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cd00043: CYCLIN (this model, PSSM-Id:238003 is obsolete and has been replaced by 410207)
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Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB is a transcription factor that binds the TATA box. Cyclins, TFIIB and RB contain 2 copies of the domain.
Links
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Statistics
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PSSM-Id: 238003
Aligned: 328 rows
Threshold Bit Score: 30.2845
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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binding site 1binding site 2
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:binding site 1
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ##     ## ##                             #           ##                         
1GUX_B     19 VYRLAYLRLNTLCERll-------sEHPELEHIIWTLFQHTLQNEyelmrdrHLDQIMMCSMYGICKVKNi-------dL 84  human
7484885    95 HVEHPHKFISNYLATl--------eTPPELRQEAWNLANDSLRTTlcv--rfRSEVVACGVVYAAARRFQvp------lP 158 thale cress
7490779   148 HIVIPHKLAIHYLQTlq------liDNKKLLQITWNFLNDASRTRlcv--lyPPFSLACGCIAMAARVIGm--------K 211 fission yeast
7497834   232 HVKHPHRLIVAYGHTlgi-----tqSRPDILQRSWNYMNDGLRTDifm--ryKPETIACACIFLAARTVEnpi---alpS 301 Caenorhabditis ele...
9759604   178 NVYHPYKPLVEAIKKfk-------vAQNALAQVAWNFVNDGLRTSlcl--qfKPHHIAAGAIFLAAKFLKvklpsdgekV 248 thale cress
AAL75565  203 HVKHPHKIIVMYLQVle------ceRNQTLVQTAWNYMNDSLRTNvfv--rfQPETIACACIYLAARALQip------lP 268 house mouse
7290261   229 HVKHPHKLIVMYLQVlq------yeKHEKLMQLSWNFMNDSLRTDvfm--ryTPEAIACACIYLSARKLNip------lP 294 fruit fly
P24863    171 IVYHPYRPLLQYVQDm--------gQEDMLLPLAWRIVNDTYRTDlcl--lyPPFMIALACLHVACVVQQkd-----arQ 235 human
XP_042114 229 GAPTISFFLEHFTHArveagqaeasEALEAQALARGVAELSLADYaft--sySPSLLAICCLALADRMLRvsr---pvdL 303 human
AAF13345  564 LTPNTLWFLNLYKEEl--------qVEEETSHISKYLADLMLLRHeli--giRPSLLASAILFLACCVTGq-------fP 626 Eufolliculina uhligi

Feature 1                                               
1GUX_B     85 KFKIIVTAYkdlphavqetfkrvlikeeeydSIIVFYNSVFM 126 human
7484885   159 ENPPWWKAFdadk---------------ssiDEVCRVLAHLY 185 thale cress
7490779   212 LPKDWYRVFdt------------------tkEEIDSLTSILE 235 fission yeast
7497834   302 TPFHWFEAFdtsd---------------rdvEAIALQLVGLY 328 Caenorhabditis elegans
9759604   249 WWQEFDVTPrq-------------------lEDVSNQMLELY 271 thale cress
AAL75565  269 TRPHWFLLFgtte---------------eeiQEICIETLRLY 295 house mouse
7290261   295 NSPPWFGIFrvpm---------------adiTDICYRVMELY 321 fruit fly
P24863    236 WFAELSVDMek-------------------iLEIIRVILKLY 258 human
XP_042114 304 RLGDHPEAAledcm-------------gklqLLVAINSTSLT 332 human
AAF13345  627 NKQMAPMYTpa------------------efTRTVTCVKEVW 650 Eufolliculina uhligi

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