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Items: 1 to 20 of 99

1.

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.

Stevens RC, Cherezov V, Katritch V, Abagyan R, Kuhn P, Rosen H, Wüthrich K.

Nat Rev Drug Discov. 2013 Jan;12(1):25-34. doi: 10.1038/nrd3859. Epub 2012 Dec 14. Review.

2.

Structural studies of G protein-coupled receptors.

Lu M, Wu B.

IUBMB Life. 2016 Nov;68(11):894-903. doi: 10.1002/iub.1578. Epub 2016 Oct 20. Review.

3.

X-ray structure breakthroughs in the GPCR transmembrane region.

Topiol S, Sabio M.

Biochem Pharmacol. 2009 Jul 1;78(1):11-20. doi: 10.1016/j.bcp.2009.02.012. Epub 2009 Feb 27. Review.

PMID:
19447219
4.

The significance of G protein-coupled receptor crystallography for drug discovery.

Salon JA, Lodowski DT, Palczewski K.

Pharmacol Rev. 2011 Dec;63(4):901-37. doi: 10.1124/pr.110.003350. Review.

5.

Applications of molecular replacement to G protein-coupled receptors.

Kruse AC, Manglik A, Kobilka BK, Weis WI.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2287-92. doi: 10.1107/S090744491301322X. Epub 2013 Oct 18.

6.

G-protein coupled receptor structure.

Yeagle PL, Albert AD.

Biochim Biophys Acta. 2007 Apr;1768(4):808-24. Epub 2006 Oct 10. Review.

7.

An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs.

Lundstrom K.

Methods Mol Biol. 2009;552:51-66. doi: 10.1007/978-1-60327-317-6_4. Review.

PMID:
19513641
8.

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.

Lee SM, Booe JM, Pioszak AA.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):196-205. doi: 10.1016/j.ejphar.2015.05.013. Epub 2015 May 14. Review.

9.

The impact of GPCR structures on pharmacology and structure-based drug design.

Congreve M, Marshall F.

Br J Pharmacol. 2010 Mar;159(5):986-96. doi: 10.1111/j.1476-5381.2009.00476.x. Epub 2009 Nov 13. Review.

10.

Structure-based and fragment-based GPCR drug discovery.

Andrews SP, Brown GA, Christopher JA.

ChemMedChem. 2014 Feb;9(2):256-75. doi: 10.1002/cmdc.201300382. Epub 2013 Dec 18. Review.

PMID:
24353016
11.

Molecular modeling of vasopressin receptor and in silico screening of V1b receptor antagonists.

Hagiwara Y, Ohno K, Kamohara M, Takasaki J, Watanabe T, Fukunishi Y, Nakamura H, Orita M.

Expert Opin Drug Discov. 2013 Aug;8(8):951-64. doi: 10.1517/17460441.2013.799134. Epub 2013 May 17. Review.

PMID:
23682717
12.

Structure of Class B GPCRs: new horizons for drug discovery.

Bortolato A, Doré AS, Hollenstein K, Tehan BG, Mason JS, Marshall FH.

Br J Pharmacol. 2014 Jul;171(13):3132-45. doi: 10.1111/bph.12689. Review.

13.

New G-protein-coupled receptor crystal structures: insights and limitations.

Kobilka B, Schertler GF.

Trends Pharmacol Sci. 2008 Feb;29(2):79-83. doi: 10.1016/j.tips.2007.11.009. Epub 2008 Jan 14. Review.

PMID:
18194818
14.

GPCR Dynamics: Structures in Motion.

Latorraca NR, Venkatakrishnan AJ, Dror RO.

Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177. Epub 2016 Sep 13. Review.

15.

Production of GPCR and GPCR complexes for structure determination.

Maeda S, Schertler GF.

Curr Opin Struct Biol. 2013 Jun;23(3):381-92. doi: 10.1016/j.sbi.2013.04.006. Epub 2013 May 24. Review.

PMID:
23707225
16.

GPCR crystal structures: Medicinal chemistry in the pocket.

Shonberg J, Kling RC, Gmeiner P, Löber S.

Bioorg Med Chem. 2015 Jul 15;23(14):3880-906. doi: 10.1016/j.bmc.2014.12.034. Epub 2014 Dec 24. Review.

PMID:
25638496
17.

Drugging specific conformational states of GPCRs: challenges and opportunities for computational chemistry.

Martí-Solano M, Schmidt D, Kolb P, Selent J.

Drug Discov Today. 2016 Apr;21(4):625-31. doi: 10.1016/j.drudis.2016.01.009. Epub 2016 Jan 25. Review.

PMID:
26821135
18.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, Hodgson S, Bodkin MJ, Singh S, Law RJ, Biggin PC.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Aug;388(8):883-903. doi: 10.1007/s00210-015-1111-8. Epub 2015 Mar 14.

19.

Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations.

Lee Y, Basith S, Choi S.

J Med Chem. 2018 Jan 11;61(1):1-46. doi: 10.1021/acs.jmedchem.6b01453. Epub 2017 Jul 21. Review.

20.

A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography.

Piscitelli CL, Kean J, de Graaf C, Deupi X.

Mol Pharmacol. 2015 Sep;88(3):536-51. doi: 10.1124/mol.115.099663. Epub 2015 Jul 7. Review.

PMID:
26152196

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