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Items: 1 to 20 of 87

1.

G protein-coupled receptor deorphanizations.

Civelli O, Reinscheid RK, Zhang Y, Wang Z, Fredriksson R, Schiöth HB.

Annu Rev Pharmacol Toxicol. 2013;53:127-46. doi: 10.1146/annurev-pharmtox-010611-134548. Epub 2012 Sep 28. Review.

2.

Orphan GPCRs and their ligands.

Civelli O, Saito Y, Wang Z, Nothacker HP, Reinscheid RK.

Pharmacol Ther. 2006 Jun;110(3):525-32. Epub 2005 Nov 9. Review.

PMID:
16289308
3.

Deorphanizing g protein-coupled receptors by a calcium mobilization assay.

Beets I, Lindemans M, Janssen T, Verleyen P.

Methods Mol Biol. 2011;789:377-91. doi: 10.1007/978-1-61779-310-3_25.

PMID:
21922422
4.

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.

Tang XL, Wang Y, Li DL, Luo J, Liu MY.

Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27. Review.

5.

Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers.

Levoye A, Dam J, Ayoub MA, Guillaume JL, Jockers R.

EMBO Rep. 2006 Nov;7(11):1094-8. Review.

6.

Identifying ligands at orphan GPCRs: current status using structure-based approaches.

Ngo T, Kufareva I, Coleman JLj, Graham RM, Abagyan R, Smith NJ.

Br J Pharmacol. 2016 Oct;173(20):2934-51. doi: 10.1111/bph.13452. Epub 2016 Mar 5. Review.

7.

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S.

J Biomol Screen. 2013 Jun;18(5):599-609. doi: 10.1177/1087057113475480. Epub 2013 Feb 8.

PMID:
23396314
8.

Bioinformatics-based discovery and identification of new biologically active peptides for GPCR deorphanization.

Colette J, Avé E, Grenier-Boley B, Coquel AS, Lesellier K, Puget K.

J Pept Sci. 2007 Sep;13(9):568-74.

PMID:
17694568
9.

The identification of ligands at orphan G-protein coupled receptors.

Wise A, Jupe SC, Rees S.

Annu Rev Pharmacol Toxicol. 2004;44:43-66. Review.

PMID:
14744238
10.

The G protein-coupled receptors deorphanization landscape.

Laschet C, Dupuis N, Hanson J.

Biochem Pharmacol. 2018 Jul;153:62-74. doi: 10.1016/j.bcp.2018.02.016. Epub 2018 Feb 15. Review.

PMID:
29454621
11.

Functional assays for identifying ligands at orphan G protein-coupled receptors.

Szekeres PG.

Receptors Channels. 2002;8(5-6):297-308. Review.

PMID:
12690957
12.

Orphan GPCR research.

Chung S, Funakoshi T, Civelli O.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S339-46. Epub 2007 Dec 10. Review.

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15.

Cellular and molecular biology of orphan G protein-coupled receptors.

Oh DY, Kim K, Kwon HB, Seong JY.

Int Rev Cytol. 2006;252:163-218. Review.

PMID:
16984818
16.

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.

Lee SM, Booe JM, Pioszak AA.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):196-205. doi: 10.1016/j.ejphar.2015.05.013. Epub 2015 May 14. Review.

17.

Ligand screening system using fusion proteins of G protein-coupled receptors with G protein alpha subunits.

Suga H, Haga T.

Neurochem Int. 2007 Jul-Sep;51(2-4):140-64. Epub 2007 Jun 19. Review.

PMID:
17659814
18.

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ.

Nat Chem Biol. 2017 Feb;13(2):235-242. doi: 10.1038/nchembio.2266. Epub 2016 Dec 19.

19.

Novel roles for arrestins in G protein-coupled receptor biology and drug discovery.

Claing A, Laporte SA.

Curr Opin Drug Discov Devel. 2005 Sep;8(5):585-9. Review.

PMID:
16159020
20.

Postgenomic characterization of G-protein-coupled receptors.

Mertens I, Vandingenen A, Meeusen T, De Loof A, Schoofs L.

Pharmacogenomics. 2004 Sep;5(6):657-72. Review.

PMID:
15335287

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