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Items: 1 to 20 of 505

1.

Emerging opportunities for allosteric modulation of G-protein coupled receptors.

Wang CI, Lewis RJ.

Biochem Pharmacol. 2013 Jan 15;85(2):153-62. doi: 10.1016/j.bcp.2012.09.001. Epub 2012 Sep 11. Review.

PMID:
22975406
2.

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation.

Peeters MC, van Westen GJ, Li Q, IJzerman AP.

Trends Pharmacol Sci. 2011 Jan;32(1):35-42. doi: 10.1016/j.tips.2010.10.001. Review.

PMID:
21075459
3.

Allosteric modulators of rhodopsin-like G protein-coupled receptors: opportunities in drug development.

Müller CE, Schiedel AC, Baqi Y.

Pharmacol Ther. 2012 Sep;135(3):292-315. doi: 10.1016/j.pharmthera.2012.06.002. Epub 2012 Jun 19. Review.

PMID:
22728155
4.

Allosteric modulation of G-protein coupled receptors.

Jensen AA, Spalding TA.

Eur J Pharm Sci. 2004 Mar;21(4):407-20. Review.

PMID:
14998571
5.

Strategies for the identification of allosteric modulators of G-protein-coupled receptors.

Burford NT, Watson J, Bertekap R, Alt A.

Biochem Pharmacol. 2011 Mar 15;81(6):691-702. doi: 10.1016/j.bcp.2010.12.012. Epub 2010 Dec 22. Review.

PMID:
21184747
6.

Emerging paradigms in GPCR allostery: implications for drug discovery.

Wootten D, Christopoulos A, Sexton PM.

Nat Rev Drug Discov. 2013 Aug;12(8):630-44. doi: 10.1038/nrd4052. Review.

PMID:
23903222
7.

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.

Antony J, Kellershohn K, Mohr-Andrä M, Kebig A, Prilla S, Muth M, Heller E, Disingrini T, Dallanoce C, Bertoni S, Schrobang J, Tränkle C, Kostenis E, Christopoulos A, Höltje HD, Barocelli E, De Amici M, Holzgrabe U, Mohr K.

FASEB J. 2009 Feb;23(2):442-50. doi: 10.1096/fj.08-114751. Epub 2008 Oct 8.

PMID:
18842964
8.

Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities.

De Amici M, Dallanoce C, Holzgrabe U, Tränkle C, Mohr K.

Med Res Rev. 2010 May;30(3):463-549. doi: 10.1002/med.20166. Review.

PMID:
19557759
9.

Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.

Mohr K, Schmitz J, Schrage R, Tränkle C, Holzgrabe U.

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):508-16. doi: 10.1002/anie.201205315. Epub 2012 Dec 6. Review.

PMID:
23225228
10.

Allosteric modulation of family C G-protein-coupled receptors: from molecular insights to therapeutic perspectives.

Urwyler S.

Pharmacol Rev. 2011 Mar;63(1):59-126. doi: 10.1124/pr.109.002501. Epub 2011 Jan 12. Review.

PMID:
21228259
11.

Allosteric modulators of G-protein-coupled receptors.

May LT, Christopoulos A.

Curr Opin Pharmacol. 2003 Oct;3(5):551-6. Review.

PMID:
14559102
12.

Conformational complexity of G-protein-coupled receptors.

Kobilka BK, Deupi X.

Trends Pharmacol Sci. 2007 Aug;28(8):397-406. Epub 2007 Jul 13. Review.

PMID:
17629961
13.

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

Valant C, Sexton PM, Christopoulos A.

Mol Interv. 2009 Jun;9(3):125-35. doi: 10.1124/mi.9.3.6. Review.

PMID:
19592673
14.

Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations.

Goupil E, Laporte SA, Hébert TE.

Mini Rev Med Chem. 2012 Aug;12(9):817-30. Review.

PMID:
22681252
15.

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

Leach K, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2007 Aug;28(8):382-9. Epub 2007 Jul 13. Review.

PMID:
17629965
16.

G protein-coupled receptor allosterism and complexing.

Christopoulos A, Kenakin T.

Pharmacol Rev. 2002 Jun;54(2):323-74. Review.

PMID:
12037145
17.

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A.

J Biol Chem. 2008 Oct 24;283(43):29312-21. doi: 10.1074/jbc.M803801200. Epub 2008 Aug 22.

18.

Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics.

Gilchrist A.

Trends Pharmacol Sci. 2007 Aug;28(8):431-7. Epub 2007 Jul 17. Review.

PMID:
17644194
19.

Novel Allosteric Modulators of G Protein-coupled Receptors.

Gentry PR, Sexton PM, Christopoulos A.

J Biol Chem. 2015 Aug 7;290(32):19478-88. doi: 10.1074/jbc.R115.662759. Epub 2015 Jun 22. Review.

20.

Allosteric properties of G protein-coupled receptor oligomers.

Springael JY, Urizar E, Costagliola S, Vassart G, Parmentier M.

Pharmacol Ther. 2007 Sep;115(3):410-8. Epub 2007 Jun 27. Review.

PMID:
17655934

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