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Items: 1 to 20 of 167

1.

Structure-based drug screening for G-protein-coupled receptors.

Shoichet BK, Kobilka BK.

Trends Pharmacol Sci. 2012 May;33(5):268-72. doi: 10.1016/j.tips.2012.03.007. Epub 2012 Apr 13. Review.

2.

Structure-based and fragment-based GPCR drug discovery.

Andrews SP, Brown GA, Christopher JA.

ChemMedChem. 2014 Feb;9(2):256-75. doi: 10.1002/cmdc.201300382. Epub 2013 Dec 18. Review.

PMID:
24353016
3.

Fragment-based lead discovery on G-protein-coupled receptors.

Visegrády A, Keserű GM.

Expert Opin Drug Discov. 2013 Jul;8(7):811-20. doi: 10.1517/17460441.2013.794135. Epub 2013 Apr 29. Review.

PMID:
23621346
4.

From purified GPCRs to drug discovery: the promise of protein-based methodologies.

Alkhalfioui F, Magnin T, Wagner R.

Curr Opin Pharmacol. 2009 Oct;9(5):629-35. doi: 10.1016/j.coph.2009.04.002. Epub 2009 May 13. Review.

PMID:
19443270
5.

The impact of GPCR structures on pharmacology and structure-based drug design.

Congreve M, Marshall F.

Br J Pharmacol. 2010 Mar;159(5):986-96. doi: 10.1111/j.1476-5381.2009.00476.x. Epub 2009 Nov 13. Review.

6.

Discovery of GPCR Ligands by Molecular Docking Screening: Novel Opportunities Provided by Crystal Structures.

Rodríguez D, Ranganathan A, Carlsson J.

Curr Top Med Chem. 2015;15(24):2484-503. Review.

PMID:
26126906
7.

Molecular modeling of vasopressin receptor and in silico screening of V1b receptor antagonists.

Hagiwara Y, Ohno K, Kamohara M, Takasaki J, Watanabe T, Fukunishi Y, Nakamura H, Orita M.

Expert Opin Drug Discov. 2013 Aug;8(8):951-64. doi: 10.1517/17460441.2013.799134. Epub 2013 May 17. Review.

PMID:
23682717
8.

Catecholamine receptors: prototypes for GPCR-based drug discovery.

Emery AC.

Adv Pharmacol. 2013;68:335-56. doi: 10.1016/B978-0-12-411512-5.00016-6. Review.

PMID:
24054152
9.

The year in G protein-coupled receptor research.

Millar RP, Newton CL.

Mol Endocrinol. 2010 Jan;24(1):261-74. doi: 10.1210/me.2009-0473. Epub 2009 Dec 17. Review.

10.

An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs.

Lundstrom K.

Methods Mol Biol. 2009;552:51-66. doi: 10.1007/978-1-60327-317-6_4. Review.

PMID:
19513641
11.

G-protein coupled receptors: advances in simulation and drug discovery.

Miao Y, McCammon JA.

Curr Opin Struct Biol. 2016 Dec;41:83-89. doi: 10.1016/j.sbi.2016.06.008. Epub 2016 Jun 22. Review.

12.

Characterizing common substructures of ligands for GPCR protein subfamilies.

Erguner B, Hattori M, Goto S, Kanehisa M.

Genome Inform. 2010;24:31-41.

13.

Emerging Approaches to GPCR Ligand Screening for Drug Discovery.

Kumari P, Ghosh E, Shukla AK.

Trends Mol Med. 2015 Nov;21(11):687-701. doi: 10.1016/j.molmed.2015.09.002. Epub 2015 Oct 16. Review.

PMID:
26481827
14.

Discovery of GPCR ligands for probing signal transduction pathways.

Brogi S, Tafi A, Désaubry L, Nebigil CG.

Front Pharmacol. 2014 Nov 28;5:255. doi: 10.3389/fphar.2014.00255. eCollection 2014. Review.

15.

Structure versus function-The impact of computational methods on the discovery of specific GPCR-ligands.

Bermudez M, Wolber G.

Bioorg Med Chem. 2015 Jul 15;23(14):3907-12. doi: 10.1016/j.bmc.2015.03.026. Epub 2015 Mar 14. Review.

PMID:
25828056
16.

Virtual screening of GPCRs: an in silico chemogenomics approach.

Jacob L, Hoffmann B, Stoven V, Vert JP.

BMC Bioinformatics. 2008 Sep 6;9:363. doi: 10.1186/1471-2105-9-363.

17.

From three-dimensional GPCR structure to rational ligand discovery.

Kooistra AJ, Leurs R, de Esch IJ, de Graaf C.

Adv Exp Med Biol. 2014;796:129-57. doi: 10.1007/978-94-007-7423-0_7. Review.

PMID:
24158804
18.

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches.

Wu Z, Lu W, Yu W, Wang T, Li W, Liu G, Zhang H, Pang X, Huang J, Liu M, Cheng F, Tang Y.

Pharmacol Res. 2018 Mar;129:400-413. doi: 10.1016/j.phrs.2017.11.005. Epub 2017 Nov 10.

PMID:
29133212
19.

Modeling and Deorphanization of Orphan GPCRs.

Diaz C, Angelloz-Nicoud P, Pihan E.

Methods Mol Biol. 2018;1705:413-429. doi: 10.1007/978-1-4939-7465-8_21.

PMID:
29188576
20.

Methods for Virtual Screening of GPCR Targets: Approaches and Challenges.

Cross JB.

Methods Mol Biol. 2018;1705:233-264. doi: 10.1007/978-1-4939-7465-8_11.

PMID:
29188566

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