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Items: 1 to 20 of 76

1.

Structural insights into adrenergic receptor function and pharmacology.

Kobilka BK.

Trends Pharmacol Sci. 2011 Apr;32(4):213-8. doi: 10.1016/j.tips.2011.02.005. Epub 2011 Mar 15. Review.

2.

Structure of β-adrenergic receptors.

Brueckner F, Piscitelli CL, Tsai CJ, Standfuss J, Deupi X, Schertler GF.

Methods Enzymol. 2013;520:117-51. doi: 10.1016/B978-0-12-391861-1.00006-X.

PMID:
23332698
3.

Structural insights into G-protein-coupled receptor activation.

Weis WI, Kobilka BK.

Curr Opin Struct Biol. 2008 Dec;18(6):734-40. doi: 10.1016/j.sbi.2008.09.010. Epub 2008 Nov 17. Review.

4.

GPCR crystal structures: Medicinal chemistry in the pocket.

Shonberg J, Kling RC, Gmeiner P, Löber S.

Bioorg Med Chem. 2015 Jul 15;23(14):3880-906. doi: 10.1016/j.bmc.2014.12.034. Epub 2014 Dec 24. Review.

PMID:
25638496
5.

Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.

Huber T, Menon S, Sakmar TP.

Biochemistry. 2008 Oct 21;47(42):11013-23. doi: 10.1021/bi800891r. Epub 2008 Sep 27.

PMID:
18821775
6.

Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development.

Archbold JK, Flanagan JU, Watkins HA, Gingell JJ, Hay DL.

Trends Pharmacol Sci. 2011 Oct;32(10):591-600. doi: 10.1016/j.tips.2011.05.007. Epub 2011 Jun 29. Review.

PMID:
21722971
7.

The beta-adrenergic receptor. Configuration, regulation, mechanism of action.

Bristow MR.

Postgrad Med. 1988 Feb 29;Spec No:19-26. Review.

PMID:
2894659
8.

β2-Adrenergic ion-channel coupled receptors as conformational motion detectors.

Caro LN, Moreau CJ, Revilloud J, Vivaudou M.

PLoS One. 2011 Mar 25;6(3):e18226. doi: 10.1371/journal.pone.0018226.

9.

New insights from structural biology into the druggability of G protein-coupled receptors.

Mason JS, Bortolato A, Congreve M, Marshall FH.

Trends Pharmacol Sci. 2012 May;33(5):249-60. doi: 10.1016/j.tips.2012.02.005. Epub 2012 Mar 30. Review.

PMID:
22465153
10.

The impact of GPCR structures on pharmacology and structure-based drug design.

Congreve M, Marshall F.

Br J Pharmacol. 2010 Mar;159(5):986-96. doi: 10.1111/j.1476-5381.2009.00476.x. Epub 2009 Nov 13. Review.

11.

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.

Lee SM, Booe JM, Pioszak AA.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):196-205. doi: 10.1016/j.ejphar.2015.05.013. Epub 2015 May 14. Review.

12.

Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease.

Hata JA, Koch WJ.

Mol Interv. 2003 Aug;3(5):264-72. Review.

PMID:
14993440
13.

Three Generations of β-blockers: History, Class Differences and Clinical Applicability.

do Vale GT, Ceron CS, Gonzaga NA, Simplicio JA, Padovan JC.

Curr Hypertens Rev. 2019;15(1):22-31. doi: 10.2174/1573402114666180918102735. Review.

PMID:
30227820
14.

GPCR agonist binding revealed by modeling and crystallography.

Katritch V, Abagyan R.

Trends Pharmacol Sci. 2011 Nov;32(11):637-43. doi: 10.1016/j.tips.2011.08.001. Epub 2011 Sep 6.

15.

Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.

Barki-Harrington L, Luttrell LM, Rockman HA.

Circulation. 2003 Sep 30;108(13):1611-8. Epub 2003 Sep 8.

PMID:
12963634
16.

Informed development of drugs acting at family B G protein-coupled receptors.

Miller LJ.

Ann N Y Acad Sci. 2008 Nov;1144:203-9. doi: 10.1196/annals.1418.001.

PMID:
19076378
17.

"Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.

Nelson CP, Challiss RA.

Biochem Pharmacol. 2007 Mar 15;73(6):737-51. Epub 2006 Sep 12. Review.

PMID:
17046719
18.

Emerging structural insights into biased GPCR signaling.

Shukla AK, Singh G, Ghosh E.

Trends Biochem Sci. 2014 Dec;39(12):594-602. doi: 10.1016/j.tibs.2014.10.001. Epub 2014 Nov 4. Review.

PMID:
25458114
19.

Pharmacological characteristics and species-related variations of beta 3-adrenergic receptors.

Pietri-Rouxel F, Strosberg AD.

Fundam Clin Pharmacol. 1995;9(3):211-8. Review.

PMID:
7557816
20.

Strategies to discover unexpected targets for drugs active at G protein-coupled receptors.

Allen JA, Roth BL.

Annu Rev Pharmacol Toxicol. 2011;51:117-44. doi: 10.1146/annurev-pharmtox-010510-100553. Review.

PMID:
20868273

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