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The Sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture.

Weiner EM, Robson S, Marohn M, Clubb RT.

J Biol Chem. 2010 Jul 23;285(30):23433-43. doi: 10.1074/jbc.M110.135434. Epub 2010 May 19.


Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESS.

Chan AH, Yi SW, Terwilliger AL, Maresso AW, Jung ME, Clubb RT.

J Biol Chem. 2015 Oct 16;290(42):25461-74. doi: 10.1074/jbc.M115.670984. Epub 2015 Aug 31.


Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism.

Frankel BA, Kruger RG, Robinson DE, Kelleher NL, McCafferty DG.

Biochemistry. 2005 Aug 23;44(33):11188-200.


Solution structure of the sortase required for efficient production of infectious Bacillus anthracis spores.

Robson SA, Jacobitz AW, Phillips ML, Clubb RT.

Biochemistry. 2012 Oct 9;51(40):7953-63. doi: 10.1021/bi300867t. Epub 2012 Sep 27.


Sorting of LPXTG peptides by archetypal sortase A: role of invariant substrate residues in modulating the enzyme dynamics and conformational signature of a productive substrate.

Biswas T, Pawale VS, Choudhury D, Roy RP.

Biochemistry. 2014 Apr 22;53(15):2515-24. doi: 10.1021/bi4016023. Epub 2014 Apr 14.


The structure of the Staphylococcus aureus sortase-substrate complex reveals how the universally conserved LPXTG sorting signal is recognized.

Suree N, Liew CK, Villareal VA, Thieu W, Fadeev EA, Clemens JJ, Jung ME, Clubb RT.

J Biol Chem. 2009 Sep 4;284(36):24465-77. doi: 10.1074/jbc.M109.022624. Epub 2009 Jul 10.


Sortase A substrate specificity in GBS pilus 2a cell wall anchoring.

Necchi F, Nardi-Dei V, Biagini M, Assfalg M, Nuccitelli A, Cozzi R, Norais N, Telford JL, Rinaudo CD, Grandi G, Maione D.

PLoS One. 2011;6(10):e25300. doi: 10.1371/journal.pone.0025300. Epub 2011 Oct 4.


Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA.

Bentley ML, Gaweska H, Kielec JM, McCafferty DG.

J Biol Chem. 2007 Mar 2;282(9):6571-81. Epub 2007 Jan 2.


Crystal structures of Staphylococcus aureus sortase A and its substrate complex.

Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV.

J Biol Chem. 2004 Jul 23;279(30):31383-9. Epub 2004 Apr 26.


Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.

Frankel BA, Tong Y, Bentley ML, Fitzgerald MC, McCafferty DG.

Biochemistry. 2007 Jun 19;46(24):7269-78. Epub 2007 May 23.


Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1.

Khare B, Krishnan V, Rajashankar KR, I-Hsiu H, Xin M, Ton-That H, Narayana SV.

PLoS One. 2011;6(8):e22995. doi: 10.1371/journal.pone.0022995. Epub 2011 Aug 30.


Elucidation of the Recognition Sequence of Sortase B from Bacillus anthracis by Using a Newly Developed Liquid Chromatography-Mass Spectrometry-Based Method.

Puorger C, Di Girolamo S, Lipps G.

Biochemistry. 2017 May 30;56(21):2641-2650. doi: 10.1021/acs.biochem.7b00108. Epub 2017 May 16.


Virtual screening of LPXTG competitive SrtA inhibitors targeting signal transduction mechanism in Bacillus anthracis: a combined experimental and theoretical study.

Selvaraj C, Sivakamavalli J, Baskaralingam V, Singh SK.

J Recept Signal Transduct Res. 2014 Jun;34(3):221-32. doi: 10.3109/10799893.2013.876044. Epub 2014 Feb 3.


Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus.

Bentley ML, Lamb EC, McCafferty DG.

J Biol Chem. 2008 May 23;283(21):14762-71. doi: 10.1074/jbc.M800974200. Epub 2008 Mar 28.


Directed evolution provides insight into conformational substrate sampling by SrtA.

Suliman M, Santosh V, Seegar TCM, Dalton AC, Schultz KM, Klug CS, Barton WA.

PLoS One. 2017 Aug 31;12(8):e0184271. doi: 10.1371/journal.pone.0184271. eCollection 2017.


Localization and mutagenesis of the sorting signal binding site on sortase A from Staphylococcus aureus.

Liew CK, Smith BT, Pilpa R, Suree N, Ilangovan U, Connolly KM, Jung ME, Clubb RT.

FEBS Lett. 2004 Jul 30;571(1-3):221-6.


Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole.

Jacobitz AW, Wereszczynski J, Yi SW, Amer BR, Huang GL, Nguyen AV, Sawaya MR, Jung ME, McCammon JA, Clubb RT.

J Biol Chem. 2014 Mar 28;289(13):8891-902. doi: 10.1074/jbc.M113.509273. Epub 2014 Feb 11.


Bacillus anthracis sortase A (SrtA) anchors LPXTG motif-containing surface proteins to the cell wall envelope.

Gaspar AH, Marraffini LA, Glass EM, Debord KL, Ton-That H, Schneewind O.

J Bacteriol. 2005 Jul;187(13):4646-55.


Sortase C-mediated anchoring of BasI to the cell wall envelope of Bacillus anthracis.

Marraffini LA, Schneewind O.

J Bacteriol. 2007 Sep;189(17):6425-36. Epub 2007 Jun 22.


Activation of inhibitors by sortase triggers irreversible modification of the active site.

Maresso AW, Wu R, Kern JW, Zhang R, Janik D, Missiakas DM, Duban ME, Joachimiak A, Schneewind O.

J Biol Chem. 2007 Aug 10;282(32):23129-39. Epub 2007 Jun 1.

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