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The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning.

Hull R, Oosthuysen B, Cajee UF, Mokgohloa L, Nweke E, Antunes RJ, Coetzer TH, Ntwasa M.

Int J Mol Sci. 2015 May 6;16(5):10242-66. doi: 10.3390/ijms160510242.


The association of RBBP6 variant 3 expressions with apoptosis in human immunodeficiency virus-associated nephropathy (HIVAN).

Mbita Z, Naicker S, Goetsch S, Dlamini Z.

Exp Mol Pathol. 2015 Aug;99(1):74-80. doi: 10.1016/j.yexmp.2015.04.005. Epub 2015 Apr 21.


RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs.

Di Giammartino DC, Li W, Ogami K, Yashinskie JJ, Hoque M, Tian B, Manley JL.

Genes Dev. 2014 Oct 15;28(20):2248-60. doi: 10.1101/gad.245787.114.


The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.

Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman-Smook H, Pugh D, Debatisse M, He F, Zhang L, Defossez PA.

Cell Rep. 2014 Apr 24;7(2):575-587. doi: 10.1016/j.celrep.2014.03.030. Epub 2014 Apr 13.


Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.

Moela P, Choene MM, Motadi LR.

Immunobiology. 2014 Aug;219(8):593-601. doi: 10.1016/j.imbio.2014.03.002. Epub 2014 Mar 21.


Overexpression of RBBP6, alone or combined with mutant TP53, is predictive of poor prognosis in colon cancer.

Chen J, Tang H, Wu Z, Zhou C, Jiang T, Xue Y, Huang G, Yan D, Peng Z.

PLoS One. 2013 Jun 17;8(6):e66524. doi: 10.1371/journal.pone.0066524. Print 2013.


The C. elegans Homolog of RBBP6 (RBPL-1) regulates fertility through controlling cell proliferation in the germline and nutrient synthesis in the intestine.

Huang P, Ma X, Zhao Y, Miao L.

PLoS One. 2013;8(3):e58736. doi: 10.1371/journal.pone.0058736. Epub 2013 Mar 11.


De-regulation of the RBBP6 isoform 3/DWNN in human cancers.

Mbita Z, Meyer M, Skepu A, Hosie M, Rees J, Dlamini Z.

Mol Cell Biochem. 2012 Mar;362(1-2):249-62. doi: 10.1007/s11010-011-1150-5. Epub 2011 Dec 3.


Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box.

Kappo MA, Ab E, Hassem F, Atkinson RA, Faro A, Muleya V, Mulaudzi T, Poole JO, McKenzie JM, Chibi M, Moolman-Smook JC, Rees DJ, Pugh DJ.

J Biol Chem. 2012 Mar 2;287(10):7146-58. doi: 10.1074/jbc.M110.217059. Epub 2011 Nov 29.


Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer.

Motadi LR, Bhoola KD, Dlamini Z.

Immunobiology. 2011 Oct;216(10):1065-73. doi: 10.1016/j.imbio.2011.05.004. Epub 2011 May 17.


Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor.

Peidis P, Giannakouros T, Burow ME, Williams RW, Scott RE.

BMC Syst Biol. 2010 Feb 25;4:14. doi: 10.1186/1752-0509-4-14.


Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis.

Singh M, Fowlkes V, Handy I, Patel CV, Patel RC.

J Mol Biol. 2009 Jan 16;385(2):457-68. doi: 10.1016/j.jmb.2008.10.068. Epub 2008 Nov 5.


RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1.

Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ.

J Mol Biol. 2008 Dec 26;384(4):908-16. doi: 10.1016/j.jmb.2008.09.060. Epub 2008 Oct 2.


The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli.

Marques JT, White CL, Peters GA, Williams BR, Sen GC.

J Interferon Cytokine Res. 2008 Aug;28(8):469-76. doi: 10.1089/jir.2007.0006.


PACT is a negative regulator of p53 and essential for cell growth and embryonic development.

Li L, Deng B, Xing G, Teng Y, Tian C, Cheng X, Yin X, Yang J, Gao X, Zhu Y, Sun Q, Zhang L, Yang X, He F.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7951-6. Epub 2007 Apr 30.


A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing.

Rowe TM, Rizzi M, Hirose K, Peters GA, Sen GC.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5823-8. Epub 2006 Mar 29.


DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.

Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ.

BMC Struct Biol. 2006 Jan 5;6:1.


Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.

Yoshitake Y, Nakatsura T, Monji M, Senju S, Matsuyoshi H, Tsukamoto H, Hosaka S, Komori H, Fukuma D, Ikuta Y, Katagiri T, Furukawa Y, Ito H, Shinohara M, Nakamura Y, Nishimura Y.

Clin Cancer Res. 2004 Oct 1;10(19):6437-48.


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