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Items: 18


The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.

Illingworth RS, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM, Adams IR, Bickmore WA.

Genes Dev. 2015 Sep 15;29(18):1897-902. doi: 10.1101/gad.268151.115.


BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.

Taherbhoy AM, Huang OW, Cochran AG.

Nat Commun. 2015 Jul 7;6:7621. doi: 10.1038/ncomms8621.


The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development.

Morimoto-Suzki N, Hirabayashi Y, Tyssowski K, Shinga J, Vidal M, Koseki H, Gotoh Y.

Development. 2014 Nov;141(22):4343-53. doi: 10.1242/dev.112276. Epub 2014 Oct 24.


Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.

Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen H, Shen B, Deng X, Zhou A, Chin YE, Rauscher FJ 3rd, Peng C, Hou Z.

Cancer Res. 2014 Aug 15;74(16):4353-63. doi: 10.1158/0008-5472.CAN-14-0181. Epub 2014 Jun 5.


Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions.

Bartocci C, Diedrich JK, Ouzounov I, Li J, Piunti A, Pasini D, Yates JR 3rd, Lazzerini Denchi E.

Cell Rep. 2014 May 22;7(4):1320-32. doi: 10.1016/j.celrep.2014.04.002. Epub 2014 May 9.


Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice.

Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H.

Hepatology. 2014 Jul;60(1):323-33. doi: 10.1002/hep.27046.


RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development.

Su WJ, Fang JS, Cheng F, Liu C, Zhou F, Zhang J.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1720-5. doi: 10.1073/pnas.1211604110. Epub 2013 Jan 14.


Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability.

Wen W, Peng C, Kim MO, Ho Jeong C, Zhu F, Yao K, Zykova T, Ma W, Carper A, Langfald A, Bode AM, Dong Z.

Oncogene. 2014 Jan 23;33(4):421-8. doi: 10.1038/onc.2012.605. Epub 2013 Jan 14.


Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.

Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG.

EMBO J. 2011 Jul 19;30(16):3285-97. doi: 10.1038/emboj.2011.243.


Structural transitions of the RING1B C-terminal region upon binding the polycomb cbox domain.

Wang R, Ilangovan U, Robinson AK, Schirf V, Schwarz PM, Lafer EM, Demeler B, Hinck AP, Kim CA.

Biochemistry. 2008 Aug 5;47(31):8007-15. doi: 10.1021/bi800857f. Epub 2008 Jul 11.


Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.

Endoh M, Endo TA, Endoh T, Fujimura Y, Ohara O, Toyoda T, Otte AP, Okano M, Brockdorff N, Vidal M, Koseki H.

Development. 2008 Apr;135(8):1513-24. doi: 10.1242/dev.014340. Epub 2008 Mar 13.


Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.

Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM.

J Biol Chem. 2006 Jul 21;281(29):20643-9. Epub 2006 May 18.


Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

Buchwald G, van der Stoop P, Weichenrieder O, Perrakis A, van Lohuizen M, Sixma TK.

EMBO J. 2006 Jun 7;25(11):2465-74. Epub 2006 May 18.


Role of histone H2A ubiquitination in Polycomb silencing.

Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y.

Nature. 2004 Oct 14;431(7010):873-8. Epub 2004 Sep 22.


Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.

Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, van Lohuizen M.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2468-73. Epub 2003 Feb 14.


The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE.

Mol Cell Biol. 2002 Sep;22(17):6070-8.


A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y.

Science. 2002 May 10;296(5570):1132-6.


E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme.

Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S.

FEBS Lett. 2001 Aug 10;503(1):61-4.

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