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Physiology (Bethesda). 2010 Oct;25(5):293-303. doi: 10.1152/physiol.00002.2010.

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.

Author information

1
Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, Catalunya, Spain. xavier.deupi@psi.ch

Abstract

G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.

PMID:
20940434
PMCID:
PMC3056154
DOI:
10.1152/physiol.00002.2010
[Indexed for MEDLINE]
Free PMC Article

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