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HomoloGene:8854. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SPOCK2,  H.sapiens
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
NP_001231879.1
424 aa
SPOCK2,  P.troglodytes
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
XP_001136277.1
424 aa
SPOCK2,  M.mulatta
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
XP_001105299.1
424 aa
SPOCK2,  C.lupus
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
XP_850525.1
424 aa
SPOCK2,  B.taurus
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
NP_001094585.1
424 aa
Spock2,  M.musculus
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
NP_443720.1
423 aa
Spock2,  R.norvegicus
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
NP_001102003.1
425 aa
spock2,  X.tropicalis
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
NP_001119987.1
419 aa
spock2,  D.rerio
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
XP_002664230.1
422 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.
Hadchouel A, et al. Am J Respir Crit Care Med 184, 1164-70 (2011).
Genome-wide meta-analyses of smoking behaviors in African Americans.
David SP, et al. Transl Psychiatry 2, e119 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SPARC_EC (cd00252)
  SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
KAZAL_FS (cl00097)
  Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
TY (cl00150)
  Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Spock2 includes H.sapiens SPOCK2.


 

 

 

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