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HomoloGene:16368. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PROKR2,  H.sapiens
prokineticin receptor 2
384 aa
PROKR2,  P.troglodytes
prokineticin receptor 2
384 aa
PROKR2,  C.lupus
prokineticin receptor 2
384 aa
PROKR2,  B.taurus
prokineticin receptor 2
384 aa
Prokr2,  M.musculus
prokineticin receptor 2
381 aa
Prokr2,  R.norvegicus
prokineticin receptor 2
421 aa
PROKR2,  G.gallus
prokineticin receptor 2
397 aa
prokr2,  X.tropicalis
prokineticin receptor 2
378 aa
LOC798231,  D.rerio
Prokineticin receptor 1-like
396 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Kallmann syndrome 3.

Articles associated with genes and sequences of this homology group.

Functional analysis of the distal region of the third intracellular loop of PROKR2.
Zhou XT, et al. Biochem Biophys Res Commun 439, 12-7 (2013).
PROKR2 mutations in autosomal recessive Kallmann syndrome.
Tommiska J, et al. Fertil Steril 99, 815-8 (2013).
An ancient founder mutation in PROKR2 impairs human reproduction.
Avbelj Stefanija M, et al. Hum Mol Genet 21, 4314-24 (2012).
PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.
Reynaud R, et al. J Clin Endocrinol Metab 97, E1068-73 (2012).
Evidence that prokineticin receptor 2 exists as a dimer in vivo.
Marsango S, et al. Cell Mol Life Sci 68, 2919-29 (2011).
PROKR2 is associated with methamphetamine dependence in the Japanese population.
Kishi T, et al. Prog Neuropsychopharmacol Biol Psychiatry 34, 1033-6 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prokr2 includes H.sapiens PROKR2 and R.norvegicus Prokr2.




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