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HomoloGene:9064. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ARAP2,  H.sapiens
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
NP_056045.2
1704 aa
ARAP2,  P.troglodytes
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
XP_001135477.1
1704 aa
ARAP2,  M.mulatta
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
XP_001090397.1
1450 aa
ARAP2,  C.lupus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
XP_545958.3
1707 aa
ARAP2,  B.taurus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
XP_002688267.2
1681 aa
Arap2,  M.musculus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
NP_848494.2
1703 aa
Arap2,  R.norvegicus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
NP_001100686.1
1672 aa
ARAP2,  G.gallus
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
XP_426346.4
1700 aa
arap2,  X.tropicalis
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
XP_002938697.2
1558 aa
LOC559690,  D.rerio
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2-like
XP_688145.6
1612 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ARAP1: a point of convergence for Arf and Rho signaling.
Miura K, et al. Mol Cell 9, 109-19 (2002).
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
Ahmeti KB, et al. Neurobiol Aging 34, 357.e7-19 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RA (pfam00788)
  Ras association (RalGDS/AF-6) domain.
PH-like (cl00273)
  Pleckstrin homology-like domain.
ArfGap (pfam01412)
  Putative GTPase activating protein for Arf.
Baculo_PP31 (pfam05311)
  Baculovirus 33KDa late protein (PP31).
UBQ (cl00155)
  Ubiquitin-like proteins.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
PH-like (cl17171)
  Pleckstrin homology-like domain.
UBQ (cl00155)
  Ubiquitin-like proteins.
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.
RhoGAP (cl02570)
  RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arap2 includes H.sapiens ARAP2 and R.norvegicus Arap2.

 

 

 

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