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HomoloGene:349. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GM2A,  H.sapiens
GM2 ganglioside activator
NP_000396.2
193 aa
GM2A,  P.troglodytes
GM2 ganglioside activator
XP_003950707.1
193 aa
LOC713375,  M.mulatta
ganglioside GM2 activator-like
XP_001109570.1
190 aa
GM2A,  C.lupus
GM2 ganglioside activator
XP_003639059.1
196 aa
GM2A,  B.taurus
GM2 ganglioside activator
NP_001192476.1
193 aa
Gm2a,  M.musculus
GM2 ganglioside activator protein
NP_034429.1
193 aa
Gm2a,  R.norvegicus
GM2 ganglioside activator
NP_758838.2
199 aa
GM2A,  G.gallus
GM2 ganglioside activator
XP_003642107.2
202 aa
gm2a,  X.tropicalis
GM2 ganglioside activator
NP_001017081.1
203 aa
LOC100495195,  X.tropicalis
ganglioside GM2 activator-like
XP_002932357.2
165 aa
gm2a,  D.rerio
GM2 ganglioside activator
NP_001017831.1
200 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
GM2-gangliosidosis, AB variant.



Publications
Articles associated with genes and sequences of this homology group.

Structural analysis of lipid complexes of GM2-activator protein.
Wright CS, et al. J Mol Biol 331, 951-64 (2003).
Requirement of GM2 ganglioside activator for phospholipase D activation.
Nakamura S, et al. Proc Natl Acad Sci U S A 95, 12249-53 (1998).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ML (cl00274)
  The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
ML (cl00274)
  The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gm2a includes H.sapiens GM2A and R.norvegicus Gm2a.

 

 

 

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