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Series GSE70302 Query DataSets for GSE70302
Status Public on Jun 27, 2015
Title Gene expression data of C57BL/6, Il1a-knockout and Il1b-knockout mice at 24 hours after spinal cord injury
Organism Mus musculus
Experiment type Expression profiling by array
Summary We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates its detrimental effect, we analyzed the transcriptome of the injured spinal cord of Il1a-KO, Il1b-KO and C57BL/6 mice at 24 hours after SCI using GeneChip microarrays.
 
Overall design Il1a-KO, Il1b-KO and C57BL/6 mice were subjected to a 50-kdyn SCI and a 6-mm spinal cord segment centered over the site of contusion extracted for RNA isolation and microarray analysis.
 
Contributor(s) Lacroix S
Citation(s) 26224856
Submission date Jun 26, 2015
Last update date Mar 04, 2019
Contact name Steve Lacroix
E-mail(s) Steve.Lacroix@crchul.ulaval.ca
Organization name Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - CHUL
Department Médecine moléculaire
Street address 2705, boul. Laurier
City Québec
State/province Québec
ZIP/Postal code G1V 4G2
Country Canada
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (12)
GSM1723397 C57BL/6 sipnal cord, biological rep1
GSM1723398 C57BL/6 sipnal cord, biological rep2
GSM1723399 C57BL/6 sipnal cord, biological rep3
Relations
BioProject PRJNA288278

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Supplementary file Size Download File type/resource
GSE70302_RAW.tar 52.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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