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Series GSE24417 Query DataSets for GSE24417
Status Public on Sep 29, 2010
Title MAQC-II Project: Iconix data set
Sample organism Rattus norvegicus
Experiment type Third-party reanalysis
Expression profiling by array
Summary The Iconix data set (endpoint B) was provided by Iconix Biosciences, Inc. (Mountain View, CA, USA). The study objective was to assess, upon short term exposure, hepatic tumor induction bynon-genotoxic chemicals, since there are currently no accurate and well-validated short-term tests to identify non-genotoxic hepatic tumorigens, thus necessitating an expensive 2-year rodent bioassay before a risk assessment can begin.
The reanalysis has been carried out with log2 transformed gene expression levels of the raw signal values.
The data in this Series were initially submitted in GEO Series GSE8251.
 
Overall design The training set consists of hepatic gene expression data from 216 male Sprague-Dawley rats treated for 5 days with one of 76 structurally and mechanistically diverse nongenotoxic hepatocarcinogens and non-hepatocarcinogens. The validation set consists of 201 male Sprague-Dawley rats treated for 5 days with one of 68 structurally and mechanistically diverse non-genotoxic hepatocarcinogens and non- hepatocarcinogens. Gene expression data were generated using the Amersham Codelink Uniset Rat 1 Bioarray (GE HealthCare, Piscataway, NJ). The separation of the training set and validation set was based on the time when the microarray data were collected; i.e., microarrays processed earlier in the study were used as training and those processed later were used as validation.
 
Citation(s) 20064235, 20676074
Submission date Sep 28, 2010
Last update date Mar 22, 2012
Contact name Leming Shi
E-mail(s) lemingshi@fudan.edu.cn
Phone +86-18616827008
Organization name Fudan University
Department School of Life Sciences
Lab Center for Pharmacogenomics
Street address 2005 Songhu Road
City Shanghai
ZIP/Postal code 200438
Country China
 
This SubSeries is part of SuperSeries:
GSE16716 MicroArray Quality Control Phase II (MAQC-II) Project
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BioProject PRJNA132719

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Supplementary file Size Download File type/resource
GSE24417_MAQC-II_TGx_Iconix417_ClinInfo_25AUG2007.xls.gz 41.3 Kb (ftp)(http) XLS
GSE24417_Training_DataMatrix.txt.gz 6.4 Mb (ftp)(http) TXT
GSE24417_Validation_DataMatrix.txt.gz 6.0 Mb (ftp)(http) TXT

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