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Series GSE161483 Query DataSets for GSE161483
Status Public on Oct 15, 2021
Title Nanostring CAR T Characterization panel comparing expression in cord blood-derived transgenic T cells cultured with IL-2 or with IL-7 and IL-15, peripheral blood-derived transgenic T cells cultured with IL-2
Organism Homo sapiens
Experiment type Other
Summary The purpose of the experiment was to transcriptionally characterize transgenic T cells derived from cord blood (CB) and cultured with IL-2 or IL-7 and IL-15, or from peripheral blood (PB) and cultured with IL-2.
The sample replicates were generated using peripheral and cord blood mononuclear cells, obtained from healthy human donors and cord blood units that were not compliant with banking standards, respectively. T cells were then transduced with a retroviral vector encoding an HLA-DRB1*04-restricted TCR targeting the human papillomavirus oncoprotein E7.
 
Overall design There are 4 sample replicates for the peripheral blood condition, all of which were cultured with IL-2, and 8 sample replicates for the cord blood condition, among which 4 were cultured with IL-2 and 4 were cultured with IL-7 and IL-15. All experiments were independent.
 
Contributor(s) Marton C
Citation(s) 34645974
Submission date Nov 13, 2020
Last update date Jan 14, 2022
Contact name Chrystel Marton
Organization name UMR1098 INSERM
Street address 8 rue du Dr Jean-François-Xavier Girod
City Besançon
ZIP/Postal code 25020
Country France
 
Platforms (1)
GPL29417 NanoString nCounter CAR-T Characterization panel
Samples (12)
GSM4908559 CB IL-2 n°1
GSM4908560 CB IL-2 n°2
GSM4908561 CB IL-2 n°3
Relations
BioProject PRJNA678379

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE161483_RAW.tar 120.0 Kb (http)(custom) TAR (of RCC)
Raw data provided as supplementary file
Processed data included within Sample table

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