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    RNF115 ring finger protein 115 [ Homo sapiens (human) ]

    Gene ID: 27246, updated on 5-Jan-2022

    Summary

    Official Symbol
    RNF115provided by HGNC
    Official Full Name
    ring finger protein 115provided by HGNC
    Primary source
    HGNC:HGNC:18154
    See related
    Ensembl:ENSG00000265491 MIM:619535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCA2; ZFP364; ZNF364; RABRING7
    Summary
    Enables ubiquitin-protein transferase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; protein autoubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in heart (RPKM 16.1), fat (RPKM 8.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RNF115 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145738868..145824095, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145611018..145696218)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 25, pseudogene Neighboring gene G protein-coupled receptor 89A Neighboring gene PDZ domain containing 1 Neighboring gene CD160 molecule Neighboring gene RNA polymerase III subunit C Neighboring gene nudix hydrolase 17 Neighboring gene microRNA 6736 Neighboring gene protein inhibitor of activated STAT 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of BCA2 by shRNA enhances HIV-1 replication in Jurkat CD4+ T cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Increased levels of ubiquitinated BCA2 are found in the presence of HIV-1 Gag, suggesting that the auto-ubiquitination activity of BCA2 increases in the absence of target proteins PubMed
    gag Replacement of cysteine residues at positions 228 and 231 with alanine in the E3 catalytic domain of BCA2 has no defect in Gag expression or processing, indicating that residues 228 and 231 are required for the antiviral activity of BCA2 PubMed
    gag A ligase-dead mutant deltaRING-BCA2 has no defect in Gag expression or processing, indicating that the intact RING-domain is required for the antiviral activity of BCA2 PubMed
    gag BCA2 has tetherin-independent antiviral activity, which results in a defect in either Gag expression or processing, impairing virus assembly and release for both HIV-1 and SIV PubMed
    gag BCA2 promotes the lysosomal degradation of HIV-1 and SIV Gag proteins and induces changes in the subcellular distribution of Gag PubMed
    gag Results from co-immunoprecipitation assays indicate that the N-terminal region (residues 1-147) of BCA2 physically interacts with the MA region (residues 1-165) of HIV-1 Gag PubMed
    gag BCA2 induces ubiquitination of both HIV-1 and SIV Gag proteins, resulting in lysine residues K113, K114, and K418 in HIV-1 Gag, and K360 and K419 residues in SIV Gag that are ubiquinated PubMed
    gag BCA2 co-localizes with HIV-1 Gag in in CD63+ endosomes/lysosomes PubMed
    Vpu vpu HIV-1 Vpu antagonizes the effects of BCA2 on HIV-1 particle production in ""tetherin-positive"" cells PubMed
    capsid gag A significant downregulation in the levels of virion-associated CA is observed in cells expressing BCA2 for both wild-type HIV-1 and Vpu-deficient HIV-1 PubMed
    matrix gag Results from co-immunoprecipitation assays indicate that the N-terminal region (residues 1-147) of BCA2 physically interacts with HIV-1 MA but not CA and NC proteins PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF115
    Names
    RING-type E3 ubiquitin transferase RNF115
    rabring 7
    zinc finger protein 364
    NP_055270.1
    XP_005273009.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014455.4NP_055270.1  E3 ubiquitin-protein ligase RNF115

      See identical proteins and their annotated locations for NP_055270.1

      Status: VALIDATED

      Source sequence(s)
      AC242845, AF419857, BG684824, HY099262
      Consensus CDS
      CCDS72863.1
      UniProtKB/Swiss-Prot
      Q9Y4L5
      Related
      ENSP00000463650.1, ENST00000582693.5
      Conserved Domains (2) summary
      pfam14369
      Location:1949
      zinc_ribbon_9; zinc-ribbon
      cd16800
      Location:226272
      RING-H2_RNF115; RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      145738868..145824095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272952.5XP_005273009.1  E3 ubiquitin-protein ligase RNF115 isoform X1

      Conserved Domains (1) summary
      pfam13639
      Location:194236
      zf-RING_2; Ring finger domain

    RNA

    1. XR_001737118.2 RNA Sequence

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