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    AP1G1 adaptor related protein complex 1 subunit gamma 1 [ Homo sapiens (human) ]

    Gene ID: 164, updated on 5-Jan-2022

    Summary

    Official Symbol
    AP1G1provided by HGNC
    Official Full Name
    adaptor related protein complex 1 subunit gamma 1provided by HGNC
    Primary source
    HGNC:HGNC:555
    See related
    Ensembl:ENSG00000166747 MIM:603533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADTG; CLAPG1; USRISD
    Summary
    Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 21.3), testis (RPKM 19.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See AP1G1 in Genome Data Viewer
    Location:
    16q22.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (71729000..71808834, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71762903..71842737, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene Sharpr-MPRA regulatory region 2747 Neighboring gene small nucleolar RNA, H/ACA box 70D Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene parathymosin pseudogene Neighboring gene tripartite motif containing 13 pseudogene Neighboring gene ataxin 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The highly conserved C-terminal dileucine motif (residues 851-856) in the cytosolic domain of HIV-1 gp41 interacts with clathrin-associated AP-1 adaptor complexes PubMed
    env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
    Nef nef Adaptor-related protein complex 1 (AP-1) is necessary for cross-presentation by MHC-I HLA-A and HLA-B molecules containing a cytoplasmic tail tyrosine signal and that HIV-1 Nef inhibits the cross-presentation in antigen-presenting cells PubMed
    nef HIV-1 Nef interaction with AP-1gamma is required for CD28 and CD8beta downregulation PubMed
    nef Exogenous Nef and TNF-alpha synergistically activate NF-kappaB and AP-1 resulting in enhancing viral replication in both chronically infected promonocytic cells and acutely infected primary macrophages PubMed
    nef Mutating three amino acids (Y320, A324, and D327) in the cytoplasmic tail of HLA-A2 abrogates Nef-induced downregulation of HLA-A2 through a failuer to recruit the mu1 or gamma subunits of AP-1 PubMed
    nef Knocking down either AP-1 gamma, AP-1 mu1, or clathrin strongly inhibits Nef-induced downregulation of HLA-A2 PubMed
    nef HIV-1 Nef stabilizes the association of AP-1 with membranes; the dileucine residues (164-165) in Nef are required for Nef binding and stabilization of the AP-1 complexes PubMed
    nef HIV-1 Nef stabilizes AP-1 complexes on endosomal membranes after ADP-ribosylation factor-1 (ARF1) -dependent attachment PubMed
    Vpu vpu Vpu interacts with clathrin adaptors AP1G1 and AP2A1 in tetherin-expressing cells and this interaction is regulated by serine phosphorylation of Vpu and Vpu binding to BST2 (tetherin) PubMed
    vpu Crystal structure indicates that Vpu L66 and V67 embed into the hydrophobic pocket on AP1 sigma 1 to accommodate the canonical dileucine residues, while Vpu E62 forms a salt bridge with R15 of AP1 gamma 1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC18255

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cargo adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    AP-1 complex subunit gamma-1
    Names
    adapter-related protein complex 1 subunit gamma-1
    adaptor protein complex AP-1 subunit gamma-1
    adaptor related protein complex 1 gamma 1 subunit
    clathrin assembly protein complex 1 gamma large chain
    clathrin assembly protein complex 1 gamma-1 large chain
    clathrin-associated/assembly/adaptor protein, large, gamma 1
    gamma adaptin
    gamma1-adaptin
    golgi adaptor HA1/AP1 adaptin gamma subunit
    golgi adaptor HA1/AP1 adaptin subunit gamma-1
    testicular tissue protein Li 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030007.2NP_001025178.1  AP-1 complex subunit gamma-1 isoform a

      See identical proteins and their annotated locations for NP_001025178.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC009097, BC036283, BU902252
      Consensus CDS
      CCDS45522.1
      UniProtKB/Swiss-Prot
      O43747
      UniProtKB/TrEMBL
      A0A140VJE7, Q8IY97
      Related
      ENSP00000377148.3, ENST00000393512.7
      Conserved Domains (4) summary
      smart00809
      Location:712820
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam05109
      Location:593654
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:142163
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:23577
      Adaptin_N; Adaptin N terminal region
    2. NM_001128.6NP_001119.3  AP-1 complex subunit gamma-1 isoform b

      See identical proteins and their annotated locations for NP_001119.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB015317, AC009097, BC036283, BU902252
      Consensus CDS
      CCDS32480.1
      UniProtKB/Swiss-Prot
      O43747
      UniProtKB/TrEMBL
      Q8IY97
      Related
      ENSP00000299980.4, ENST00000299980.9
      Conserved Domains (4) summary
      smart00809
      Location:709817
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam05109
      Location:590651
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:142163
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:23574
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      71729000..71808834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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