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    KIF20A kinesin family member 20A [ Homo sapiens (human) ]

    Gene ID: 10112, updated on 25-Jan-2022

    Summary

    Official Symbol
    KIF20Aprovided by HGNC
    Official Full Name
    kinesin family member 20Aprovided by HGNC
    Primary source
    HGNC:HGNC:9787
    See related
    Ensembl:ENSG00000112984 MIM:605664; AllianceGenome:HGNC:9787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RCM6; MKLP2; RAB6KIFL
    Summary
    Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Broad expression in testis (RPKM 7.6), bone marrow (RPKM 5.2) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KIF20A in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (138179112..138187723)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137514801..137523412)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 888, pseudogene Neighboring gene NME/NM23 family member 5 Neighboring gene bromodomain containing 8 Neighboring gene Sharpr-MPRA regulatory region 11877 Neighboring gene cell division cycle 23 Neighboring gene Sharpr-MPRA regulatory region 7870 Neighboring gene GDNF family receptor alpha 3 Neighboring gene RPS27A pseudogene 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21151

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in midbody abscission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF20A
    Names
    GG10_2
    RAB6 interacting, kinesin-like (rabkinesin6)
    mitotic kinesin-like protein 2
    rab6-interacting kinesin-like protein
    rabkinesin-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005733.3NP_005724.1  kinesin-like protein KIF20A

      See identical proteins and their annotated locations for NP_005724.1

      Status: VALIDATED

      Source sequence(s)
      AC106752, AK025790, BC012999, DC402781
      Consensus CDS
      CCDS4199.1
      UniProtKB/Swiss-Prot
      O95235
      Related
      ENSP00000378356.3, ENST00000394894.8
      Conserved Domains (2) summary
      cd01368
      Location:63505
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      cl25732
      Location:547795
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      138179112..138187723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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