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    ATG7 autophagy related 7 [ Homo sapiens (human) ]

    Gene ID: 10533, updated on 25-Jan-2022

    Summary

    Official Symbol
    ATG7provided by HGNC
    Official Full Name
    autophagy related 7provided by HGNC
    Primary source
    HGNC:HGNC:16935
    See related
    Ensembl:ENSG00000197548 MIM:608760; AllianceGenome:HGNC:16935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSA7; APG7L; SCAR31; APG7-LIKE
    Summary
    This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 10.0), thyroid (RPKM 8.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ATG7 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (11272348..11564652)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11314083..11606126)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene histamine receptor H1 Neighboring gene Sharpr-MPRA regulatory region 13806 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene uncharacterized LOC105376952 Neighboring gene Sharpr-MPRA regulatory region 8254 Neighboring gene vestigial like family member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Spinocerebellar ataxia, autosomal recessive 31
    MedGen: CN301114 OMIM: 619422 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of autophagy related 7 homolog (ATG7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The siRNA-mediated reduction of ATG7 protein reverses Torin-1-induced HIV-1 Tat degradation, suggesting ATG7 is involved in the lysosomal-mediated Tat degradation PubMed
    capsid gag Knockdown of autophagy factor ATG7 results in diminished levels of p24 yields in both primary monocyte- and U937-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp434N0735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Atg12 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Atg12 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables Atg8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in C-terminal protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagy of mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to hyperoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in late nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein modification process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein lipidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in suppression by virus of host autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like modifier-activating enzyme ATG7
    Names
    APG7 autophagy 7-like
    ATG12-activating enzyme E1 ATG7
    hAGP7
    ubiquitin-activating enzyme E1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136031.3NP_001129503.2  ubiquitin-like modifier-activating enzyme ATG7 isoform b

      See identical proteins and their annotated locations for NP_001129503.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AC022001, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS46752.1
      UniProtKB/Swiss-Prot
      O95352
      Related
      ENSP00000347042.5, ENST00000354956.9
      Conserved Domains (1) summary
      cl25654
      Location:15675
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. NM_001144912.2NP_001138384.1  ubiquitin-like modifier-activating enzyme ATG7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c.
      Source sequence(s)
      AC022001, AK303694, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS46753.1
      UniProtKB/Swiss-Prot
      O95352
      Related
      ENSP00000412580.2, ENST00000446450.6
      Conserved Domains (3) summary
      cd01486
      Location:318616
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15614
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13282
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    3. NM_001349232.2NP_001336161.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Related
      ENSP00000510336.1, ENST00000693202.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    4. NM_001349233.2NP_001336162.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, 6, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Related
      ENSP00000509725.1, ENST00000685771.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    5. NM_001349234.2NP_001336163.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    6. NM_001349235.2NP_001336164.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4, 5, and 6, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    7. NM_001349236.2NP_001336165.1  ubiquitin-like modifier-activating enzyme ATG7 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform d.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cl25654
      Location:15663
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    8. NM_001349237.2NP_001336166.1  ubiquitin-like modifier-activating enzyme ATG7 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform e.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cl25654
      Location:15649
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    9. NM_001349238.2NP_001336167.1  ubiquitin-like modifier-activating enzyme ATG7 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform f.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    10. NM_006395.3NP_006386.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      See identical proteins and their annotated locations for NP_006386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 4, 5, 6, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC022001, AK075221, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      O95352
      UniProtKB/TrEMBL
      B3KQM6
      Related
      ENSP00000346437.3, ENST00000354449.7
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      11272348..11564652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005547.2XP_016861036.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X5

    2. XM_011533286.2XP_011531588.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X10

      See identical proteins and their annotated locations for XP_011531588.1

      UniProtKB/Swiss-Prot
      O95352
      Conserved Domains (1) summary
      cl25654
      Location:15675
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    3. XM_011533283.2XP_011531585.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X6

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    4. XM_011533285.3XP_011531587.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X8

      Conserved Domains (3) summary
      TIGR01381
      Location:15640
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
      cl22428
      Location:357629
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
    5. XM_011533280.2XP_011531582.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X3

      Conserved Domains (3) summary
      cd01486
      Location:357655
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15666
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    6. XM_011533277.3XP_011531579.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_011531579.1

      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    7. XM_011533281.2XP_011531583.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X4

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15695
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    8. XM_011533284.2XP_011531586.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X7

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    9. XM_011533279.2XP_011531581.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

      Conserved Domains (1) summary
      cl25654
      Location:15694
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    10. XM_017005549.2XP_016861038.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X8

      Conserved Domains (3) summary
      TIGR01381
      Location:15640
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
      cl22428
      Location:357629
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
    11. XM_006712932.4XP_006712995.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712995.1

      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    12. XM_017005548.1XP_016861037.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X6

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    13. XM_017005551.1XP_016861040.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X11

    14. XM_017005543.1XP_016861032.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X3

      Conserved Domains (3) summary
      cd01486
      Location:357655
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15666
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    15. XM_006712931.4XP_006712994.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712994.1

      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    16. XM_024453312.1XP_024309080.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

      Conserved Domains (1) summary
      cl25654
      Location:15694
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    17. XM_017005550.1XP_016861039.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X9

    18. XM_011533278.2XP_011531580.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_011531580.1

      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    19. XM_024453315.1XP_024309083.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X13

      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    20. XM_024453314.1XP_024309082.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X12

      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    21. XM_006712933.3XP_006712996.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712996.1

      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    22. XM_017005542.1XP_016861031.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      Conserved Domains (1) summary
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    23. XM_024453313.1XP_024309081.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X12

      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...

    RNA

    1. XR_940363.2 RNA Sequence

      Related
      ENST00000435760.6
    2. XR_001739980.2 RNA Sequence

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