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    CTU1 cytosolic thiouridylase subunit 1 [ Homo sapiens (human) ]

    Gene ID: 90353, updated on 5-Jan-2022

    Summary

    Official Symbol
    CTU1provided by HGNC
    Official Full Name
    cytosolic thiouridylase subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:29590
    See related
    Ensembl:ENSG00000142544 MIM:612694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCS6; ATPBD3
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in kidney (RPKM 1.5), spleen (RPKM 1.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CTU1 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51097606..51108409, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51600863..51611666, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985341 Neighboring gene kallikrein related peptidase 14 Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene sialic acid binding Ig like lectin 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC17332

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein urmylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA thio-modification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tRNA wobble uridine modification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic tRNA wobble base thiouridylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoplasmic tRNA 2-thiolation protein 1
    Names
    ATP binding domain 3
    ATP-binding domain-containing protein 3
    cancer-associated gene protein
    cancer-associated protein
    cytoplasmic tRNA adenylyltransferase 1
    cytosolic thiouridylase subunit 1 homolog
    NP_660275.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145232.4NP_660275.2  cytoplasmic tRNA 2-thiolation protein 1

      See identical proteins and their annotated locations for NP_660275.2

      Status: VALIDATED

      Source sequence(s)
      AC011473, AK291173, BX440723
      Consensus CDS
      CCDS12824.1
      UniProtKB/Swiss-Prot
      Q7Z7A3
      Related
      ENSP00000390011.1, ENST00000421832.3
      Conserved Domains (3) summary
      TIGR00269
      Location:207308
      TIGR00269; TIGR00269 family protein
      COG0037
      Location:54322
      TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
      cd01993
      Location:54243
      Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      51097606..51108409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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