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    SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 [ Homo sapiens (human) ]

    Gene ID: 9806, updated on 12-Oct-2019

    Summary

    Official Symbol
    SPOCK2provided by HGNC
    Official Full Name
    SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2provided by HGNC
    Primary source
    HGNC:HGNC:13564
    See related
    Ensembl:ENSG00000107742 MIM:607988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    testican-2
    Summary
    This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Biased expression in lung (RPKM 58.9), brain (RPKM 55.4) and 13 other tissues See more
    Orthologs

    Genomic context

    See SPOCK2 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (72059034..72095313, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73818792..73848790, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NFE2L2 motif-containing MPRA enhancers 43 and 138 Neighboring gene carbohydrate sulfotransferase 3 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene anaphase promoting complex subunit 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
    NHGRI GWA Catalog
    Genome-wide meta-analyses of smoking behaviors in African Americans.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ97039

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycosaminoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    synapse assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    testican-2
    Names
    SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
    SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134434.1NP_001127906.1  testican-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001127906.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) shares only the two most-5' exons with variant 2 and has a distinct exon at its 3' end. This results in a protein (isoform 1) with a severely truncated C-terminus that lacks a SPARC_EC domain when compared to isoform 2.
      Source sequence(s)
      AA922448, AK307091, AW026489, DA150747, DC305070
      Consensus CDS
      CCDS44431.1
      UniProtKB/Swiss-Prot
      Q92563
      Related
      ENSP00000397715.1, ENST00000412663.5
    2. NM_001244950.2NP_001231879.1  testican-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001231879.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a different 5' UTR, compared to variant 2. Variants 2 and 3 encode the same protein (isoform 2).
      Source sequence(s)
      AC022392, BC023558, BQ029472
      Consensus CDS
      CCDS7313.1
      UniProtKB/Swiss-Prot
      Q92563
      Related
      ENSP00000362201.2, ENST00000373109.7
      Conserved Domains (4) summary
      smart00280
      Location:147180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:312376
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:198316
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:197303
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
    3. NM_014767.2NP_055582.1  testican-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_055582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer protein (isoform 2). Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC022392, AY358921, BP252465, BQ002304, D87465, DA150747, DC305070
      Consensus CDS
      CCDS7313.1
      UniProtKB/Swiss-Prot
      Q92563
      Related
      ENSP00000321108.4, ENST00000317376.8
      Conserved Domains (4) summary
      smart00280
      Location:147180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:312376
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:198316
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:197303
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      72059034..72095313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540404.3XP_011538706.1  testican-2 isoform X1

      See identical proteins and their annotated locations for XP_011538706.1

      UniProtKB/TrEMBL
      A0A024QZQ5
      Related
      ENSP00000439445.2, ENST00000536168.2
      Conserved Domains (4) summary
      smart00280
      Location:144177
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:309373
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:195313
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:194300
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
    2. XM_017016985.2XP_016872474.1  testican-2 isoform X2

      UniProtKB/Swiss-Prot
      Q92563
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