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    ALD4 aldehyde dehydrogenase (NADP(+)) ALD4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854556, updated on 7-Nov-2021

    Summary

    Gene symbol
    ALD4
    Gene description
    aldehyde dehydrogenase (NADP(+)) ALD4
    Primary source
    SGD:S000005901
    Locus tag
    YOR374W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALD7
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    Genomic context

    See ALD4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1039840..1041399)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ndd1p Neighboring gene Nud1p Neighboring gene glutamate dehydrogenase (NADP(+)) GDH1 Neighboring gene uncharacterized protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the ALD4 gene: The ALD4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, K.lactis, A.thaliana, rice, and frog.

    Gene Ontology Provided by GO

    Process Evidence Code Pubs
    involved_in NADPH regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in acetate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ethanol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyruvate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    aldehyde dehydrogenase (NADP(+)) ALD4
    NP_015019.1
    • Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1039840..1041399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183794.1NP_015019.1  TPA: aldehyde dehydrogenase (NADP(+)) ALD4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015019.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46367
      Conserved Domains (1) summary
      cd07091
      Location:42514
      ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins
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