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    ABHD14B abhydrolase domain containing 14B [ Homo sapiens (human) ]

    Gene ID: 84836, updated on 23-Nov-2021

    Summary

    Official Symbol
    ABHD14Bprovided by HGNC
    Official Full Name
    abhydrolase domain containing 14Bprovided by HGNC
    Primary source
    HGNC:HGNC:28235
    See related
    Ensembl:ENSG00000114779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIB; HEL-S-299
    Expression
    Ubiquitous expression in fat (RPKM 33.8), kidney (RPKM 32.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ABHD14B in Genome Data Viewer
    Location:
    3p21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (51968510..51974630, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52002526..52008646, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4 Neighboring gene ABHD14A-ACY1 readthrough Neighboring gene Sharpr-MPRA regulatory region 207 Neighboring gene abhydrolase domain containing 14A Neighboring gene aminoacylase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC15429

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein ABHD14B
    Names
    CCG1-interacting factor B
    abhydrolase domain-containing protein 14B
    alpha/beta hydrolase domain-containing protein 14B
    cell cycle gene 1-interacting factor B
    epididymis secretory protein Li 299
    epididymis secretory sperm binding protein
    NP_001139786.1
    NP_001241682.1
    NP_116139.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146314.2NP_001139786.1  protein ABHD14B isoform 1

      See identical proteins and their annotated locations for NP_001139786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK096073, BC056411
      Consensus CDS
      CCDS2842.1
      UniProtKB/Swiss-Prot
      Q96IU4
      UniProtKB/TrEMBL
      V9HW87
      Related
      ENSP00000354841.5, ENST00000361143.10
      Conserved Domains (2) summary
      PLN02679
      Location:150209
      PLN02679; hydrolase, alpha/beta fold family protein
      COG0596
      Location:8136
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    2. NM_001254753.1NP_001241682.1  protein ABHD14B isoform 3

      See identical proteins and their annotated locations for NP_001241682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, which includes the translational start codon, compared to variant 1. The encoded protein is shorter and has a distinct N-terminus.
      Source sequence(s)
      AK096073, BU732936
      UniProtKB/Swiss-Prot
      Q96IU4
      Related
      ENST00000487005.1
      Conserved Domains (2) summary
      COG0596
      Location:102171
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:53150
      Abhydrolase_5; Alpha/beta hydrolase family
    3. NM_032750.3NP_116139.1  protein ABHD14B isoform 1

      See identical proteins and their annotated locations for NP_116139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK096073, BC007234
      Consensus CDS
      CCDS2842.1
      UniProtKB/Swiss-Prot
      Q96IU4
      UniProtKB/TrEMBL
      V9HW87
      Related
      ENSP00000378455.2, ENST00000395008.6
      Conserved Domains (2) summary
      PLN02679
      Location:150209
      PLN02679; hydrolase, alpha/beta fold family protein
      COG0596
      Location:8136
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      51968510..51974630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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