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    Mfap4 microfibrillar-associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 76293, updated on 10-Aug-2021

    Summary

    Official Symbol
    Mfap4provided by MGI
    Official Full Name
    microfibrillar-associated protein 4provided by MGI
    Primary source
    MGI:MGI:1342276
    See related
    Ensembl:ENSMUSG00000042436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110007F23Rik
    Expression
    Biased expression in lung adult (RPKM 558.6), limb E14.5 (RPKM 254.4) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mfap4 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61376257..61379536)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61485431..61488708)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (61298946..61302206)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12271 Neighboring gene ring finger protein 112 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbohydrate derivative binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in UV protection ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement activation, lectin pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in elastic fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of collagen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in elastic fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microfibril-associated glycoprotein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347545.1NP_001334474.1  microfibril-associated glycoprotein 4 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA270684, AL604029
      Consensus CDS
      CCDS83820.1
      UniProtKB/Swiss-Prot
      Q9D1H9
      Related
      ENSMUSP00000038971.7, ENSMUST00000040522.7
    2. NM_001361359.1NP_001348288.1  microfibril-associated glycoprotein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604029
      Related
      ENSMUST00000126308.2
      Conserved Domains (1) summary
      cd00087
      Location:29247
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    3. NM_029568.3NP_083844.1  microfibril-associated glycoprotein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_083844.1

      Status: VALIDATED

      Source sequence(s)
      AL604029
      Consensus CDS
      CCDS24813.1
      UniProtKB/Swiss-Prot
      Q9D1H9
      Related
      ENSMUSP00000070848.4, ENSMUST00000064783.10
      Conserved Domains (1) summary
      cd00087
      Location:38256
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61376257..61379536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246411.2XP_030102271.1  microfibril-associated glycoprotein 4 isoform X1

      Conserved Domains (1) summary
      cd00087
      Location:1183
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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