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    Kansl2 KAT8 regulatory NSL complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 69612, updated on 25-Nov-2021

    Summary

    Official Symbol
    Kansl2provided by MGI
    Official Full Name
    KAT8 regulatory NSL complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1916862
    See related
    Ensembl:ENSMUSG00000022992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930009D17; 2310037I24Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.7), CNS E14 (RPKM 22.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kansl2 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98415539..98432649, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98517658..98534770, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (98349532..98364652, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lactalbumin, alpha Neighboring gene olfactory receptor 278, pseudogene 1 Neighboring gene olfactory receptor 279 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene microRNA 1291 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene testis expressed 49 Neighboring gene adenylate cyclase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC101985, MGC102368

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H4-K16 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K5 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K8 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone H3-K4 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of dosage compensation by inactivation of X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    KAT8 regulatory NSL complex subunit 2
    Names
    NSL complex protein NSL2
    non-specific lethal 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289437.1NP_001276366.1  KAT8 regulatory NSL complex subunit 2 isoform b

      See identical proteins and their annotated locations for NP_001276366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK162714, BC083325, BI134551, CJ059354
      Consensus CDS
      CCDS88832.1
      UniProtKB/Swiss-Prot
      Q8BQR4
      Related
      ENSMUSP00000112101.4, ENSMUST00000116400.4
      Conserved Domains (1) summary
      pfam13891
      Location:2892
      zf-C3Hc3H; Potential DNA-binding domain
    2. NM_001289438.1NP_001276367.1  KAT8 regulatory NSL complex subunit 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC138221, AK046649, AK162714, BI134551, CJ059354
      UniProtKB/Swiss-Prot
      Q8BQR4
      Conserved Domains (1) summary
      pfam13891
      Location:173230
      zf-C3Hc3H; Potential DNA-binding domain
    3. NM_001289439.1NP_001276368.1  KAT8 regulatory NSL complex subunit 2 isoform d

      See identical proteins and their annotated locations for NP_001276368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AK046649, AK162714, AK168499, BI134551, CJ059354
      UniProtKB/Swiss-Prot
      Q8BQR4
      Conserved Domains (1) summary
      pfam13891
      Location:112169
      zf-C3Hc3H; Potential DNA-binding domain
    4. NM_001289440.1NP_001276369.1  KAT8 regulatory NSL complex subunit 2 isoform d

      See identical proteins and their annotated locations for NP_001276369.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AK046649, AK162714, AK168499, BI134551, CJ059354
      UniProtKB/Swiss-Prot
      Q8BQR4
      Conserved Domains (1) summary
      pfam13891
      Location:112169
      zf-C3Hc3H; Potential DNA-binding domain
    5. NM_001359827.1NP_001346756.1  KAT8 regulatory NSL complex subunit 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants 1 and 6 encode the same protein.
      Source sequence(s)
      AC138221
      Consensus CDS
      CCDS37190.1
      Conserved Domains (1) summary
      pfam13891
      Location:2892
      zf-C3Hc3H; Potential DNA-binding domain
    6. NM_133714.5NP_598475.2  KAT8 regulatory NSL complex subunit 2 isoform a

      See identical proteins and their annotated locations for NP_598475.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 6 encode the same protein.
      Source sequence(s)
      AK046649, AK162714, BI134551, CJ059354
      Consensus CDS
      CCDS37190.1
      UniProtKB/Swiss-Prot
      Q8BQR4
      Related
      ENSMUSP00000155089.2, ENSMUST00000230542.2
      Conserved Domains (1) summary
      pfam13891
      Location:2892
      zf-C3Hc3H; Potential DNA-binding domain

    RNA

    1. NR_153345.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138221, AEKQ02119723

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98415539..98432649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316743.3XP_017172232.1  KAT8 regulatory NSL complex subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam13891
      Location:112169
      zf-C3Hc3H; Potential DNA-binding domain
    2. XM_036159568.1XP_036015461.1  KAT8 regulatory NSL complex subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam13891
      Location:2892
      zf-C3Hc3H; Potential DNA-binding domain
    3. XM_030248754.2XP_030104614.1  KAT8 regulatory NSL complex subunit 2 isoform X3

      Conserved Domains (1) summary
      pfam13891
      Location:173230
      zf-C3Hc3H; Potential DNA-binding domain
    4. XM_030248755.2XP_030104615.1  KAT8 regulatory NSL complex subunit 2 isoform X4

      Conserved Domains (1) summary
      pfam13891
      Location:112169
      zf-C3Hc3H; Potential DNA-binding domain
    5. XM_036159569.1XP_036015462.1  KAT8 regulatory NSL complex subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam13891
      Location:2892
      zf-C3Hc3H; Potential DNA-binding domain
    6. XM_030248753.2XP_030104613.1  KAT8 regulatory NSL complex subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam13891
      Location:2892
      zf-C3Hc3H; Potential DNA-binding domain

    RNA

    1. XR_384040.5 RNA Sequence

    2. XR_004938869.1 RNA Sequence

    3. XR_003951435.2 RNA Sequence

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