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    Coq8a coenzyme Q8A [ Mus musculus (house mouse) ]

    Gene ID: 67426, updated on 31-Aug-2021

    Summary

    Official Symbol
    Coq8aprovided by MGI
    Official Full Name
    coenzyme Q8Aprovided by MGI
    Primary source
    MGI:MGI:1914676
    See related
    Ensembl:ENSMUSG00000026489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adck; Cabc; Adck3; Cabc1; AI462003; mKIAA0451; 4632432J16Rik
    Expression
    Broad expression in heart adult (RPKM 105.5), liver adult (RPKM 98.7) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Coq8a in Genome Data Viewer
    Location:
    1; 1 H4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179992803..180023585, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180165238..180196020, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182095369..182126151, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase alpha Neighboring gene predicted gene, 50608 Neighboring gene predicted gene, 38331 Neighboring gene uncharacterized LOC108167750 Neighboring gene predicted gene, 37336

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extrinsic component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    atypical kinase COQ8A, mitochondrial
    Names
    aarF domain containing kinase 3
    aarF domain-containing protein kinase 3
    atypical kinase ADCK3, mitochondrial
    chaperone activity of bc1 complex-like, mitochondrial
    chaperone, ABC1 activity of bc1 complex like
    coenzyme Q protein 8A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163290.1NP_001156762.1  atypical kinase COQ8A, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001156762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC132436
      Consensus CDS
      CCDS15566.1
      UniProtKB/Swiss-Prot
      Q60936
      Related
      ENSMUSP00000128290.2, ENSMUST00000170472.8
      Conserved Domains (1) summary
      cd13970
      Location:292542
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    2. NM_001359268.1NP_001346197.1  atypical kinase COQ8A, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132436
      Conserved Domains (1) summary
      cd13970
      Location:252502
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    3. NM_001359269.1NP_001346198.1  atypical kinase COQ8A, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132436
      Conserved Domains (1) summary
      cd13970
      Location:158408
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    4. NM_023341.3NP_075830.2  atypical kinase COQ8A, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_075830.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC132436, AK004791, AK014605, BY261815
      Consensus CDS
      CCDS15566.1
      UniProtKB/Swiss-Prot
      Q60936
      Related
      ENSMUSP00000027766.7, ENSMUST00000027766.13
      Conserved Domains (1) summary
      cd13970
      Location:292542
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      179992803..180023585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496962.2XP_006497025.1  atypical kinase COQ8A, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006497025.1

      UniProtKB/Swiss-Prot
      Q60936
      Conserved Domains (1) summary
      cd13970
      Location:292542
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
    2. XM_006496961.2XP_006497024.1  atypical kinase COQ8A, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006497024.1

      UniProtKB/Swiss-Prot
      Q60936
      Conserved Domains (1) summary
      cd13970
      Location:292542
      ABC1_ADCK3; Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3
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