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    SLCO1A2 solute carrier organic anion transporter family member 1A2 [ Homo sapiens (human) ]

    Gene ID: 6579, updated on 23-Nov-2021

    Summary

    Official Symbol
    SLCO1A2provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 1A2provided by HGNC
    Primary source
    HGNC:HGNC:10956
    See related
    Ensembl:ENSG00000084453 MIM:602883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATP; OATP-A; OATP1A2; SLC21A3
    Summary
    This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Expression
    Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLCO1A2 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21264600..21419634, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21417534..21572568, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SLCO1B3-SLCO1B7 readthrough Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene islet amyloid polypeptide Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene RecQ like helicase Neighboring gene golgi transport 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association meta-analysis for total serum bilirubin levels.
    GeneReviews: Not available
    Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    GeneReviews: Not available
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in bile acid and bile salt transport TAS
    Traceable Author Statement
    more info
     
    involved_in organic anion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1A2
    Names
    OATP-1
    organic anion transporting polypeptide A
    organic anion-transporting polypeptide 1
    sodium-independent organic anion transporter
    solute carrier family 21 (organic anion transporter), member 3
    solute carrier family 21 member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386878.1NP_001373807.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    2. NM_001386879.1NP_001373808.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Related
      ENSP00000508235.1, ENST00000683939.1
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    3. NM_001386880.1NP_001373809.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    4. NM_001386881.1NP_001373810.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    5. NM_001386882.2NP_001373811.1  solute carrier organic anion transporter family member 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    6. NM_001386886.1NP_001373815.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    7. NM_001386887.1NP_001373816.1  solute carrier organic anion transporter family member 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18538
      MFS; Major Facilitator Superfamily
    8. NM_001386890.1NP_001373819.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    9. NM_001386908.1NP_001373837.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1538
      oat; sodium-independent organic anion transporter
    10. NM_001386919.1NP_001373848.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1538
      oat; sodium-independent organic anion transporter
    11. NM_001386920.1NP_001373849.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    12. NM_001386921.1NP_001373850.1  solute carrier organic anion transporter family member 1A2 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1525
      oat; sodium-independent organic anion transporter
    13. NM_001386922.1NP_001373851.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    14. NM_001386926.1NP_001373855.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    15. NM_001386927.1NP_001373856.1  solute carrier organic anion transporter family member 1A2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1538
      oat; sodium-independent organic anion transporter
    16. NM_001386929.1NP_001373858.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    17. NM_001386931.1NP_001373860.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    18. NM_001386937.1NP_001373866.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC006559, AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    19. NM_001386938.1NP_001373867.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Related
      ENSP00000394854.1, ENST00000458504.5
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    20. NM_001386939.1NP_001373868.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    21. NM_001386940.1NP_001373869.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    22. NM_001386946.1NP_001373875.1  solute carrier organic anion transporter family member 1A2 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    23. NM_001386947.1NP_001373876.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    24. NM_001386948.1NP_001373877.1  solute carrier organic anion transporter family member 1A2 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    25. NM_001386949.1NP_001373878.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    26. NM_001386951.1NP_001373880.1  solute carrier organic anion transporter family member 1A2 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1517
      MFS; Major Facilitator Superfamily
    27. NM_001386952.1NP_001373881.1  solute carrier organic anion transporter family member 1A2 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    28. NM_001386953.1NP_001373882.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    29. NM_001386954.1NP_001373883.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    30. NM_001386958.1NP_001373887.1  solute carrier organic anion transporter family member 1A2 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    31. NM_001386959.1NP_001373888.1  solute carrier organic anion transporter family member 1A2 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1518
      MFS; Major Facilitator Superfamily
    32. NM_001386960.1NP_001373889.1  solute carrier organic anion transporter family member 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:18536
      MFS; Major Facilitator Superfamily
    33. NM_001386961.1NP_001373890.1  solute carrier organic anion transporter family member 1A2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1469
      oat; sodium-independent organic anion transporter
    34. NM_001386962.1NP_001373891.1  solute carrier organic anion transporter family member 1A2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      TIGR00805
      Location:1493
      oat; sodium-independent organic anion transporter
    35. NM_001386963.1NP_001373892.1  solute carrier organic anion transporter family member 1A2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Conserved Domains (1) summary
      cl28910
      Location:1451
      MFS; Major Facilitator Superfamily
    36. NM_021094.4NP_066580.1  solute carrier organic anion transporter family member 1A2 isoform 1

      See identical proteins and their annotated locations for NP_066580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
      Source sequence(s)
      AC022224, BX093727, DA216595, U21943
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721
      UniProtKB/TrEMBL
      A0A024RAT5
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    37. NM_134431.5NP_602307.1  solute carrier organic anion transporter family member 1A2 isoform 1

      See identical proteins and their annotated locations for NP_602307.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
      Source sequence(s)
      AC006559, AC022224
      Consensus CDS
      CCDS8686.1
      UniProtKB/Swiss-Prot
      P46721
      UniProtKB/TrEMBL
      A0A024RAT5
      Related
      ENSP00000305974.6, ENST00000307378.10
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter

    RNA

    1. NR_170340.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
    2. NR_170341.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
    3. NR_170343.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022224
      Related
      ENST00000480394.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      21264600..21419634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520819.1XP_011519121.1  solute carrier organic anion transporter family member 1A2 isoform X1

      See identical proteins and their annotated locations for XP_011519121.1

      UniProtKB/Swiss-Prot
      P46721
      UniProtKB/TrEMBL
      A0A024RAT5
      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    2. XM_024449138.1XP_024304906.1  solute carrier organic anion transporter family member 1A2 isoform X1

      Conserved Domains (1) summary
      TIGR00805
      Location:1625
      oat; sodium-independent organic anion transporter
    3. XM_011520821.2XP_011519123.1  solute carrier organic anion transporter family member 1A2 isoform X6

      Conserved Domains (1) summary
      cd01330
      Location:127180
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    4. XM_017019849.1XP_016875338.1  solute carrier organic anion transporter family member 1A2 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005075.2: Suppressed sequence

      Description
      NM_005075.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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