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    Mcm3ap minichromosome maintenance complex component 3 associated protein [ Mus musculus (house mouse) ]

    Gene ID: 54387, updated on 2-Oct-2021

    Summary

    Official Symbol
    Mcm3approvided by MGI
    Official Full Name
    minichromosome maintenance complex component 3 associated proteinprovided by MGI
    Primary source
    MGI:MGI:1930089
    See related
    Ensembl:ENSMUSG00000001150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GANP
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.2), CNS E14 (RPKM 10.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mcm3ap in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76304736..76351693)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76468902..76515859)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75931716..75978602)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pericentrin (kendrin) Neighboring gene RIKEN cDNA 1700094J05 gene Neighboring gene RIKEN cDNA 2610028H24 gene Neighboring gene ybeY metallopeptidase Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene lanosterol synthase Neighboring gene spermatogenesis and centriole associated 1 like Neighboring gene predicted gene 15343

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0572

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables H3 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    germinal-center associated nuclear protein
    Names
    80 kDa MCM3-associated protein
    GC-associated DNA primase
    minichromosome maintenance deficient 3-associated protein
    nuclear protein GANP
    NP_062307.2
    XP_006513957.1
    XP_036011786.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019434.3NP_062307.2  germinal-center associated nuclear protein

      See identical proteins and their annotated locations for NP_062307.2

      Status: VALIDATED

      Source sequence(s)
      BC052452, BC067414, BY004673
      Consensus CDS
      CCDS23947.1
      UniProtKB/Swiss-Prot
      Q9WUU9
      Related
      ENSMUSP00000125960.2, ENSMUST00000170795.3
      Conserved Domains (6) summary
      cd12443
      Location:429500
      RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
      pfam03399
      Location:679903
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam13634
      Location:36117
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16766
      Location:11571226
      CID_GANP; Binding region of GANP to ENY2
      pfam16768
      Location:3286
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
      pfam16769
      Location:12541967
      MCM3AP_GANP; MCM3AP domain of GANP

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76304736..76351693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155893.1XP_036011786.1  germinal-center associated nuclear protein isoform X1

      Conserved Domains (3) summary
      pfam03399
      Location:1229
      SAC3_GANP; SAC3/GANP family
      pfam16766
      Location:464533
      CID_GANP; Binding region of GANP to ENY2
      pfam16769
      Location:5611274
      MCM3AP_GANP; MCM3AP domain of GANP
    2. XM_006513894.3XP_006513957.1  germinal-center associated nuclear protein isoform X1

      Conserved Domains (3) summary
      pfam03399
      Location:1229
      SAC3_GANP; SAC3/GANP family
      pfam16766
      Location:464533
      CID_GANP; Binding region of GANP to ENY2
      pfam16769
      Location:5611274
      MCM3AP_GANP; MCM3AP domain of GANP
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