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    ANXA13 annexin A13 [ Homo sapiens (human) ]

    Gene ID: 312, updated on 23-Nov-2021

    Summary

    Official Symbol
    ANXA13provided by HGNC
    Official Full Name
    annexin A13provided by HGNC
    Primary source
    HGNC:HGNC:536
    See related
    Ensembl:ENSG00000104537 MIM:602573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ISA; ANX13
    Summary
    This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 128.9), small intestine (RPKM 99.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See ANXA13 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (123680794..123737393, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124693034..124749633, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375738 Neighboring gene kelch like family member 38 Neighboring gene uncharacterized LOC105375739 Neighboring gene family with sequence similarity 91 member A1 Neighboring gene fer-1 like family member 6 Neighboring gene FER1L6 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    GeneReviews: Not available
    Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150460

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylglycerol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    annexin A13
    Names
    annexin XIII
    annexin, intestine-specific
    annexin-13
    intestine-specific annexin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003954.3NP_001003954.1  annexin A13 isoform b

      See identical proteins and their annotated locations for NP_001003954.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in the coding region, compared to variant 1. The resulting isoform (b) is longer, compared to isoform a.
      Source sequence(s)
      AC011134, AC135166
      Consensus CDS
      CCDS34939.1
      UniProtKB/Swiss-Prot
      P27216
      UniProtKB/TrEMBL
      Q53FB5
      Related
      ENSP00000262219.6, ENST00000262219.10
      Conserved Domains (1) summary
      pfam00191
      Location:290355
      Annexin; Annexin
    2. NM_004306.4NP_004297.2  annexin A13 isoform a

      See identical proteins and their annotated locations for NP_004297.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript, and encodes the shorter isoform (a).
      Source sequence(s)
      AC011134, AC135166
      Consensus CDS
      CCDS47917.1
      UniProtKB/Swiss-Prot
      P27216
      UniProtKB/TrEMBL
      Q53FB5
      Related
      ENSP00000390809.1, ENST00000419625.6
      Conserved Domains (1) summary
      pfam00191
      Location:249314
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      123680794..123737393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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