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    Gulo gulonolactone (L-) oxidase [ Mus musculus (house mouse) ]

    Gene ID: 268756, updated on 16-Oct-2021

    Summary

    Official Symbol
    Guloprovided by MGI
    Official Full Name
    gulonolactone (L-) oxidaseprovided by MGI
    Primary source
    MGI:MGI:1353434
    See related
    Ensembl:ENSMUSG00000034450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLO; LGO; sfx; unh; unhip; AU018375; BC028822; 5730581M22
    Expression
    Biased expression in liver adult (RPKM 119.3), liver E18 (RPKM 17.3) and 2 other tissues See more
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    Genomic context

    See Gulo in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66224235..66246703, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65986786..66009254, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66605624..66628047, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19222 Neighboring gene clusterin Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene epoxide hydrolase 2, cytoplasmic

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29968, MGC37793, MGC37880

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-arabinono-1,4-lactone oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-gulonolactone oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-gulonolactone oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    L-gulonolactone oxidase
    Names
    L-gulono-gamma-lactone oxidase
    NP_848862.1
    XP_006519129.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178747.3NP_848862.1  L-gulonolactone oxidase

      See identical proteins and their annotated locations for NP_848862.1

      Status: PROVISIONAL

      Source sequence(s)
      AC126444
      Consensus CDS
      CCDS36958.1
      UniProtKB/Swiss-Prot
      P58710
      Related
      ENSMUSP00000060912.8, ENSMUST00000059970.9
      Conserved Domains (1) summary
      TIGR01678
      Location:7433
      FAD_lactone_ox; sugar 1,4-lactone oxidases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      66224235..66246703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519066.1XP_006519129.1  L-gulonolactone oxidase isoform X1

      See identical proteins and their annotated locations for XP_006519129.1

      UniProtKB/Swiss-Prot
      P58710
      Conserved Domains (1) summary
      TIGR01678
      Location:7433
      FAD_lactone_ox; sugar 1,4-lactone oxidases

    RNA

    1. XR_001781125.1 RNA Sequence

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