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    Sds serine dehydratase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25044, updated on 30-Sep-2021

    Summary

    Official Symbol
    Sdsprovided by RGD
    Official Full Name
    serine dehydrataseprovided by RGD
    Primary source
    RGD:67376
    See related
    EnsemblRapid:ENSRNOG00000001388
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sdh; TDH; SDH2; Sdhe1; RATSDHE1
    Summary
    enzyme that converts L-serine to pyruvate and ammonia; involved in gluconeogenesis [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 90.4) and Kidney (RPKM 25.4) See more
    Orthologs
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    Genomic context

    See Sds in Genome Data Viewer
    Location:
    12q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36083226..36090540, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41620429..41627741, complement)

    Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase-like Neighboring gene uncharacterized LOC108352452 Neighboring gene LIM homeobox 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Homology

    Clone Names

    • MGC108581

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-serine ammonia-lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-serine ammonia-lyase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables L-threonine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-serine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in isoleucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyruvate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cobalamin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in threonine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    L-serine dehydratase/L-threonine deaminase
    Names
    L-serine deaminase
    L-threonine dehydratase
    NP_446414.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053962.3NP_446414.3  L-serine dehydratase/L-threonine deaminase

      See identical proteins and their annotated locations for NP_446414.3

      Status: PROVISIONAL

      Source sequence(s)
      BC088110
      UniProtKB/Swiss-Prot
      P09367
      Related
      ENSRNOP00000001875.3, ENSRNOT00000001875.5
      Conserved Domains (1) summary
      cd06448
      Location:10320
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

      Range
      36083226..36090540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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