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    Itga8 integrin alpha 8 [ Mus musculus (house mouse) ]

    Gene ID: 241226, updated on 23-Jun-2021

    Summary

    Official Symbol
    Itga8provided by MGI
    Official Full Name
    integrin alpha 8provided by MGI
    Primary source
    MGI:MGI:109442
    See related
    Ensembl:ENSMUSG00000026768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI447669
    Summary
    This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in lung adult (RPKM 16.4), bladder adult (RPKM 4.7) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Itga8 in Genome Data Viewer
    Location:
    2 A1; 2 9.12 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (12111443..12306796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (12106632..12301985, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (12028287..12223547, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm30 Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene RIKEN cDNA E030013I19 gene Neighboring gene MINDY lysine 48 deubiquitinase 3 Neighboring gene predicted gene 13321

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metanephros development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001309.3NP_001001309.1  integrin alpha-8 preproprotein

      See identical proteins and their annotated locations for NP_001001309.1

      Status: REVIEWED

      Source sequence(s)
      AK033007, AK044910, AK135193, AL845313, BC137793, BQ175493
      Consensus CDS
      CCDS15689.1
      UniProtKB/Swiss-Prot
      A2ARA8
      Related
      ENSMUSP00000028106.5, ENSMUST00000028106.11
      Conserved Domains (3) summary
      smart00191
      Location:382436
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:10341048
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:482933
      Integrin_alpha2; Integrin alpha

    RNA

    1. NR_138462.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK033007, AK044910, AL845313, BC137793, BQ175493
      Related
      ENSMUST00000172791.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      12111443..12306796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497475.4XP_006497538.1  integrin alpha-8 isoform X1

      Conserved Domains (3) summary
      smart00191
      Location:382436
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:10511065
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:482933
      Integrin_alpha2; Integrin alpha
    2. XM_006497476.4XP_006497539.1  integrin alpha-8 isoform X2

      Conserved Domains (2) summary
      pfam00357
      Location:592606
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:23474
      Integrin_alpha2; Integrin alpha
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