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    FBP1 fructose-bisphosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 2203, updated on 19-Sep-2021

    Summary

    Official Symbol
    FBP1provided by HGNC
    Official Full Name
    fructose-bisphosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:3606
    See related
    Ensembl:ENSG00000165140 MIM:611570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBP
    Summary
    Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 175.9), kidney (RPKM 118.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FBP1 in Genome Data Viewer
    Location:
    9q22.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (94603133..94640263, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97365415..97402545, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987100 Neighboring gene leishmanolysin like peptidase pseudogene Neighboring gene RNA, U6 small nuclear 669, pseudogene Neighboring gene prostate cancer associated transcript 7 Neighboring gene fructose-bisphosphatase 2 Neighboring gene uncharacterized LOC107987101 Neighboring gene aminopeptidase O (putative) Neighboring gene microRNA 2278

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Fructose-biphosphatase deficiency Compare labs
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 Matrix activates fructose 1,6-bisphosphatase gene expression by induction of a 1alpha-hydroxylase activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables monosaccharide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sucrose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase 1
    Names
    D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
    FBPase 1
    growth-inhibiting protein 17
    liver FBPase
    NP_000498.2
    NP_001121100.1
    XP_006717068.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008174.1 RefSeqGene

      Range
      5001..42117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000507.4NP_000498.2  fructose-1,6-bisphosphatase 1

      See identical proteins and their annotated locations for NP_000498.2

      Status: REVIEWED

      Source sequence(s)
      BC012927, DA962803
      Consensus CDS
      CCDS6712.1
      UniProtKB/Swiss-Prot
      P09467
      Related
      ENSP00000364475.5, ENST00000375326.9
      Conserved Domains (1) summary
      cd00354
      Location:18332
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
    2. NM_001127628.2NP_001121100.1  fructose-1,6-bisphosphatase 1

      See identical proteins and their annotated locations for NP_001121100.1

      Status: REVIEWED

      Source sequence(s)
      AL161728
      Consensus CDS
      CCDS6712.1
      UniProtKB/Swiss-Prot
      P09467
      UniProtKB/TrEMBL
      Q2TU34
      Related
      ENSP00000408025.1, ENST00000415431.5
      Conserved Domains (1) summary
      cd00354
      Location:18332
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      94603133..94640263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717005.4XP_006717068.1  fructose-1,6-bisphosphatase 1 isoform X1

      Conserved Domains (1) summary
      cd00354
      Location:2250
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
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