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    Ubb ubiquitin B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192255, updated on 25-Nov-2021

    Summary

    Official Symbol
    Ubbprovided by RGD
    Official Full Name
    ubiquitin Bprovided by RGD
    Primary source
    RGD:621562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    mediates ATP-dependent degradation of denatured proteins [RGD, Feb 2006]
    Expression
    Biased expression in Testes (RPKM 9372.8), Brain (RPKM 6561.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ubb in Genome Data Viewer
    Location:
    10q23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47247629..47249335)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48880231..48881896)

    Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene centromere protein V Neighboring gene hypothetical protein LOC691761 Neighboring gene thymosin beta-4-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene transient receptor potential cation channel, subfamily V, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tag IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fat pad development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within female meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hypothalamus gonadotrophin-releasing hormone neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138895.2NP_620250.2  polyubiquitin-B precursor

      Status: VALIDATED

      Source sequence(s)
      BC078726, FM053084, FM072119, FN803398
      Conserved Domains (2) summary
      cd01803
      Location:153228
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

      Range
      47247629..47249335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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