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    Lox lysyl oxidase [ Mus musculus (house mouse) ]

    Gene ID: 16948, updated on 16-Oct-2021

    Summary

    Official Symbol
    Loxprovided by MGI
    Official Full Name
    lysyl oxidaseprovided by MGI
    Primary source
    MGI:MGI:96817
    See related
    Ensembl:ENSMUSG00000024529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rrg; TSC-160; AI893619
    Summary
    This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 47.6), ovary adult (RPKM 19.3) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Lox in Genome Data Viewer
    Location:
    18 D1; 18 28.22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52649132..52662939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52516060..52529867, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (52676892..52689362, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ferritin mitochondrial Neighboring gene serum response factor binding protein 1 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 41724

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-lysine 6-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-lysine 6-oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-lysine 6-oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ascending aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to chemokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within connective tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within descending aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within elastic fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-lysine oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein oxidation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-lysine 6-oxidase
    Names
    ras excision protein
    NP_001273110.1
    NP_001273111.1
    NP_034858.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286181.1NP_001273110.1  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_001273110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161119, AK141995, AK164634, BB840428, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TP83, Q3TXH3
      Conserved Domains (2) summary
      PHA03247
      Location:57159
      PHA03247; large tegument protein UL36; Provisional
      pfam01186
      Location:207408
      Lysyl_oxidase; Lysyl oxidase
    2. NM_001286182.1NP_001273111.1  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_001273111.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC109203, AK164634, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TP83, Q3TXH3
      Related
      ENSMUSP00000129247.2, ENSMUST00000171470.8
      Conserved Domains (2) summary
      PHA03247
      Location:57159
      PHA03247; large tegument protein UL36; Provisional
      pfam01186
      Location:207408
      Lysyl_oxidase; Lysyl oxidase
    3. NM_010728.3NP_034858.2  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_034858.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161119, AK141995, AK164634, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TP83, Q3TXH3
      Related
      ENSMUSP00000025409.8, ENSMUST00000025409.9
      Conserved Domains (2) summary
      PHA03247
      Location:57159
      PHA03247; large tegument protein UL36; Provisional
      pfam01186
      Location:207408
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52649132..52662939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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