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    Krt4 keratin 4 [ Mus musculus (house mouse) ]

    Gene ID: 16682, updated on 16-Oct-2021

    Summary

    Official Symbol
    Krt4provided by MGI
    Official Full Name
    keratin 4provided by MGI
    Primary source
    MGI:MGI:96701
    See related
    Ensembl:ENSMUSG00000059668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K4; Krt2-4; Krt-2.4; AW108092
    Expression
    Biased expression in lung adult (RPKM 371.2), stomach adult (RPKM 351.0) and 1 other tissue See more
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    Genomic context

    See Krt4 in Genome Data Viewer
    Location:
    15 F2; 15 57.13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101826970..101833170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101918535..101924735, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (101748966..101755166, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 77 Neighboring gene keratin 76 Neighboring gene keratin 79 Neighboring gene keratin 78

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in keratin filament TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 4
    Names
    57kDa keratin
    57kd keratin
    CK-4
    cytokeratin-4
    cytoskeletal 57 kDa keratin
    keratin complex 2, basic, gene 4
    type-II keratin Kb4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008475.2NP_032501.2  keratin, type II cytoskeletal 4

      See identical proteins and their annotated locations for NP_032501.2

      Status: VALIDATED

      Source sequence(s)
      BC064008, BY139439
      Consensus CDS
      CCDS37222.1
      UniProtKB/Swiss-Prot
      P07744
      Related
      ENSMUSP00000023797.7, ENSMUST00000023797.8
      Conserved Domains (3) summary
      pfam00038
      Location:146458
      Filament; Intermediate filament protein
      pfam16208
      Location:14142
      Keratin_2_head; Keratin type II head
      cl23720
      Location:366433
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101826970..101833170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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