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    Prmt2 protein arginine N-methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15468, updated on 23-Jun-2021

    Summary

    Official Symbol
    Prmt2provided by MGI
    Official Full Name
    protein arginine N-methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1316652
    See related
    Ensembl:ENSMUSG00000020230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrmt1; Hrmt1l1; AI504737
    Expression
    Broad expression in CNS E18 (RPKM 82.6), whole brain E14.5 (RPKM 68.0) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Prmt2 in Genome Data Viewer
    Location:
    10 C1; 10 38.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76043060..76073699, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76207226..76237865, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75669967..75700610, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5, member 4a Neighboring gene ribosomal protein L32 pseudogene Neighboring gene microRNA 678 Neighboring gene S100 protein, beta polypeptide, neural Neighboring gene disco interacting protein 2 homolog A Neighboring gene predicted gene, 40699

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC148245, MGC148246

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables progesterone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in developmental cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leptin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in methylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tyrosine phosphorylation of STAT protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 2
    Names
    heterogeneous nuclear ribonucleoprotein methyltransferase-like 1
    histone-arginine N-methyltransferase PRMT2
    NP_001071106.1
    NP_001289894.1
    NP_573445.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077638.2NP_001071106.1  protein arginine N-methyltransferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001071106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in isoform 2, which is shorter than isoform 1. Variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AI504737, AK144412, AK159186, BY288156
      Consensus CDS
      CCDS35942.1
      UniProtKB/TrEMBL
      Q3UKX1
      Related
      ENSMUSP00000097166.4, ENSMUST00000099571.10
      Conserved Domains (4) summary
      cd02440
      Location:153253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:4698
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
      pfam05185
      Location:143427
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17173
      Location:122181
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001302965.1NP_001289894.1  protein arginine N-methyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001289894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represent the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI504737, AK146966, BY288156
      Consensus CDS
      CCDS78836.1
      UniProtKB/TrEMBL
      Q3UID4
      Related
      ENSMUSP00000097167.4, ENSMUST00000099572.10
      Conserved Domains (3) summary
      cd02440
      Location:153253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:4698
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
      cl17173
      Location:122181
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_133182.3NP_573445.2  protein arginine N-methyltransferase 2 isoform 2

      See identical proteins and their annotated locations for NP_573445.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in isoform 2, which is shorter than isoform 1. Variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AI504737, AK159186, BY288156, BY727303
      Consensus CDS
      CCDS35942.1
      UniProtKB/TrEMBL
      Q3UKX1
      Related
      ENSMUSP00000020452.6, ENSMUST00000020452.12
      Conserved Domains (4) summary
      cd02440
      Location:153253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cd11806
      Location:4698
      SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
      pfam05185
      Location:143427
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17173
      Location:122181
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_126571.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon and uses an alternate splice site in an internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI504737, AK146754, BY288156
      Related
      ENSMUST00000128099.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76043060..76073699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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